AURA3: Rash

Project Patient Voice is intended to be used with a healthcare professional when discussing the potential symptoms related to a cancer and cancer treatment. Do not rely on Project Patient Voice alone to make decisions about medical care. Do not use Project Patient Voice to substitute for advice from your health care professional. Conclusions about patient experiences with symptoms may be limited because not all symptoms may have been captured by the patient-reported questionnaire.

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In AURA3 Study, Patients Were Asked: "In the last 7 days, did you have any RASH?"

Patients reported the occurrence of their Rash on a 2-point scale (No, Yes)

Patient-Reported Rash During the First 24 Weeks on Treatment for Patients Who Completed a Questionnaire:

Figure 1 shows the percentage of patients reporting if they had Rash at each time point. For example, at week 2, 30% of patients taking Tagrisso reported Rash. The range of patients who had any Rash during the first 24 weeks of treatment with Tagrisso was between 21% - 35%. Click here for more information on how to read the graphs below.

Figure 1. Patient-Reported Rash During the First 24 Weeks on Treatment

Two stacked bar charts, one for Tagrisso and the other for chemotherapy, showing proportion of patients reporting the occurrence of rash at each time point through the first 24 weeks of treatment. For example, at week 2, 30% of patients taking Tagrisso reported an occurrence of rash.

All responses from patients' experiences just before and up to week 24 on-treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.

Any Rash Occurrence That Patients Reported During the First 24 Weeks on Treatment

Figure 2. Any Patient-Reported Rash During the First 24 Weeks on Treatment

Two pie charts, one for Tagrisso and the other for chemotherapy, summarizing the percentage of patients who reported any rash during the first 24 weeks of the clinical trial. In the Tagrisso arm, No (30%), and Yes (70%). In the chemotherapy arm, No (53%) and Yes (47%).

Patients with at least one on-treatment Rash score were included in the analysis. Tagrisso (N=99), Chemotherapy (N=55).

Some Patients Did Not Report Rash Before Treatment:

For patients that did not report Rash before treatment, Figure 3 shows the percentage of patients reporting if they had Rash between weeks 1 and 24.

Figure 3. Patient-Reported Rash During the First 24 Weeks on Treatment: Patients Without Rash Before Treatment

Two stacked bar charts, one for Tagrisso and the other for chemotherapy, which includes only those patients who had no rash before treatment. The bar charts show the proportion of patients reporting occurrence of rash at each time point through 24 weeks. For example, at week 2, 22% of patients taking Tagrisso reported an occurrence of rash.

All responses from patients who did not report Rash before treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.

Any Rash Occurrence That Patients Reported During the First 24 Weeks on Treatment, for Patients Who Did Not Have Rash Before Treatment:

Figure 4. Any Patient-Reported Rash During the First 24 Weeks on Treatment: Patients Without Rash Before Treatment

Two pie charts, one for Tagrisso and the other for chemotherapy, which includes only those patients who had no rash before treatment. The pie charts summarize the percentage of patients who reported any rash. In the Tagrisso arm, No (29%) and Yes (71%). In the chemotherapy arm, No (57%) and Yes (43%).

Patients who had no Rash before treatment and at least one on-treatment Rash score were included in the analysis. Tagrisso (N=52), Chemotherapy (N=35).