AURA3: Dry skin

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In AURA3 Study, Patients Were Asked: "In the last 7 days, what was the SEVERITY of your DRY SKIN at its WORST?"

Patients scored the severity of their Dry Skin on a 5-point scale (None, Mild, Moderate, Severe, Very Severe)

Patient-Reported Dry Skin During the First 24 Weeks on Treatment for Patients Who Completed a Questionnaire:

Figure 1 shows the percentage of patients reporting the severity of their Dry Skin at each time point. For example, at week 2, 63% of patients taking Tagrisso reported Dry Skin (ranging from Mild to Severe). The range of patients who had any Dry Skin during the first 24 weeks of treatment with Tagrisso was between 48% - 70%. Click here for more information on how to read the graphs below.

Figure 1. Patient-Reported Dry Skin During the First 24 Weeks on Treatment

Two stacked bar charts, one for Tagrisso and the other for chemotherapy, showing proportion of patients reporting the severity of dry skin at each time point through the first 24 weeks of treatment. For example, at week 2, 63% of patients taking Tagrisso reported dry skin (ranging from mild to severe).

All responses from patients' experiences just before and up to week 24 on-treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.

Worst Response Option for Dry Skin That Patients Reported During the First 24 Weeks on Treatment

Figure 2. Worst Patient-Reported Dry Skin During the First 24 Weeks on Treatment

Two pie charts, one for Tagrisso and the other for chemotherapy, summarizing the percentage of patients by worst reported dry skin during the first 24 weeks of the clinical trial. In the Tagrisso arm, None (8%), Mild (38%), Moderate (44%), Severe (8%) and Very severe (2%). In the chemotherapy arm, None (7%), Mild (44%), Moderate (36%), Severe (9%) and Very severe (4%).

Patients with at least one on-treatment Dry Skin score were included in the analysis. Tagrisso (N=99), Chemotherapy (N=55).

Some Patients Did Not Report Dry Skin Before Treatment:

For patients that did not report Dry Skin before treatment, Figure 3 shows the percentage of patients reporting the severity of their Dry Skin between weeks 1 and 24.

Figure 3. Patient-Reported Dry Skin During the First 24 Weeks on Treatment: Patients Without Dry Skin Before Treatment

Two stacked bar charts, one for Tagrisso and the other for chemotherapy, which includes only those patients who had no dry skin before treatment. The bar charts show the proportion of patients reporting severity of dry skin at each time point through 24 weeks. For example, at week 2, 30% of patients taking Tagrisso reported mild dry skin.

All responses from patients who did not report Dry Skin before treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.

Worst Response Option for Dry Skin That Patients Reported During the First 24 Weeks on Treatment, for Patients Who Did Not Have Dry Skin Before Treatment:

Figure 4. Worst Patient-Reported Dry Skin During the First 24 Weeks on Treatment: Patients Without Dry Skin Before Treatment

Two pie charts, one for Tagrisso and the other for chemotherapy, which includes only those patients who had no dry skin before treatment. The pie charts summarize the percentage of patients by worst reported dry skin. In the Tagrisso arm, None (27%), Mild (50%), Moderate (18%), Severe (5%) and Very severe (0%). In the chemotherapy arm, None (40%), Mild (50%), Moderate (10%), Severe (0%) and Very severe (0%).

Patients who had no Dry Skin before treatment and at least one on-treatment Dry Skin score were included in the analysis. Tagrisso (N=22), Chemotherapy (N=10).