AURA3: Diarrhea
Project Patient Voice is intended to be used with a healthcare professional when discussing the potential symptoms related to a cancer and cancer treatment. Do not rely on Project Patient Voice alone to make decisions about medical care. Do not use Project Patient Voice to substitute for advice from your health care professional. Conclusions about patient experiences with symptoms may be limited because not all symptoms may have been captured by the patient-reported questionnaire.
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In AURA3 Study, Patients Were Asked: "In the last 7 days, how OFTEN did you have LOOSE OR WATERY STOOLS (DIARRHEA/DIARRHOEA)?"
Patients scored the frequency of their Diarrhea on a 5-point scale (Never, Rarely, Occasionally, Frequently, Almost Constantly)
Patient-Reported Diarrhea During the First 24 Weeks on Treatment for Patients Who Completed a Questionnaire:
Figure 1 shows the percentage of patients reporting how often they had Diarrhea at each time point. For example, at week 2, 43% of patients taking Tagrisso reported Diarrhea (ranging from Rarely to Frequently). The range of patients who had any Diarrhea during the first 24 weeks of treatment with Tagrisso was between 34% - 53%. Click here for more information on how to read the graphs below.
Figure 1. Patient-Reported Diarrhea During the First 24 Weeks on Treatment
All responses from patients' experiences just before and up to week 24 on-treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.
Worst Response Option for Diarrhea That Patients Reported During the First 24 Weeks on Treatment
Figure 2. Worst Patient-Reported Diarrhea During the First 24 Weeks on Treatment
Patients with at least one on-treatment Diarrhea score were included in the analysis. Tagrisso (N=99), Chemotherapy (N=55).
Some Patients Did Not Report Diarrhea Before Treatment:
For patients that did not report Diarrhea before treatment, Figure 3 shows the percentage of patients reporting how often they had Diarrhea between weeks 1 and 24.
Figure 3. Patient-Reported Diarrhea During the First 24 Weeks on Treatment: Patients Without Diarrhea Before Treatment
All responses from patients who did not report Diarrhea before treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.
Worst Response Option for Diarrhea That Patients Reported During the First 24 Weeks on Treatment, for Patients Who Did Not Have Diarrhea Before Treatment:
Figure 4. Worst Patient-Reported Diarrhea During the First 24 Weeks on Treatment: Patients Without Diarrhea Before Treatment
Patients who had no Diarrhea before treatment and at least one on-treatment Diarrhea score were included in the analysis. Tagrisso (N=55), Chemotherapy (N=27).