AURA3: Bruising
Project Patient Voice is intended to be used with a healthcare professional when discussing the potential symptoms related to a cancer and cancer treatment. Do not rely on Project Patient Voice alone to make decisions about medical care. Do not use Project Patient Voice to substitute for advice from your health care professional. Conclusions about patient experiences with symptoms may be limited because not all symptoms may have been captured by the patient-reported questionnaire.
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In AURA3 Study, Patients Were Asked: "In the last 7 days, did you BRUISE EASILY (BLACK AND BLUE MARKS)?"
Patients reported the occurrence of their Bruising on a 2-point scale (No, Yes)
Patient-Reported Bruising During the First 24 Weeks on Treatment for Patients Who Completed a Questionnaire:
Figure 1 shows the percentage of patients reporting if they had Bruising at each time point. For example, at week 2, 11% of patients taking Tagrisso reported Bruising. The range of patients who had any Bruising during the first 24 weeks of treatment with Tagrisso was between 9% - 21%. Click here for more information on how to read the graphs below.
Figure 1. Patient-Reported Bruising During the First 24 Weeks on Treatment
All responses from patients' experiences just before and up to week 24 on-treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.
Any Bruising Occurrence That Patients Reported During the First 24 Weeks on Treatment
Figure 2. Any Patient-Reported Bruising During the First 24 Weeks on Treatment
Patients with at least one on-treatment Bruising score were included in the analysis. Tagrisso (N=99), Chemotherapy (N=55).
Some Patients Did Not Report Bruising Before Treatment:
For patients that did not report Bruising before treatment, Figure 3 shows the percentage of patients reporting if they had Bruising between weeks 1 and 24.
Figure 3. Patient-Reported Bruising During the First 24 Weeks on Treatment: Patients Without Bruising Before Treatment
All responses from patients who did not report Bruising before treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.
Any Bruising Occurrence That Patients Reported During the First 24 Weeks on Treatment, for Patients Who Did Not Have Bruising Before Treatment:
Figure 4. Any Patient-Reported Bruising During the First 24 Weeks on Treatment: Patients Without Bruising Before Treatment
Patients who had no Bruising before treatment and at least one on-treatment Bruising score were included in the analysis. Tagrisso (N=75), Chemotherapy (N=34).