External Peer Review of the Expanded Decision Tree: Ranking Toxic Potential
Title of the Review:
External Peer Review of the Expanded Decision Tree: Ranking Toxic Potential
Tentative Assessment:
Highly Influential Scientific Information
Agency Contact:
Szabina Stice
Office or Center:
Center for Food Safety and Applied Nutrition
Subject of the Review:
The Expanded Decision Tree (EDT), a screening tool that would provide a consistent, systematic, science-based approach to help prioritize chemicals for evaluation. The EDT is a modernized version of the original Cramer Decision Tree.
Purpose of the Review:
To solicit comments and feedback on FDA’s approach on the development of the EDT.
Type of Review:
Individual Reviews (Letter Review)
Timing of Review:
Spring/Summer 2024
Number of Reviewers:
4-6
Primary Disciplines/Types of Expertise of Reviewers:
Organic chemistry; structure-toxicity relationships; read-across; Cramer Decision Tree (1978); Threshold of Toxicological concern concept
Reviewers Selected by:
Designated Outside Organization.
Opportunities for the Public to Comment:
No.
If yes, briefly state how and when will these opportunities be provided:
N/a.
Peer Reviewers Provided with Public Comments:
No.