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  5. Submitted 75-Day Premarket Notifications for New Dietary Ingredients
  1. New Dietary Ingredient (NDI) Notification Process

Submitted 75-Day Premarket Notifications for New Dietary Ingredients

The spreadsheet available for download from this page contains a list of publicly displayable New Dietary Ingredient Notifications (NDINs) that we have reviewed to date. For each NDIN, there is a link to information at http://www.regulations.gov relevant to that notification. The notifications are organized by the NDIN number and are sortable and searchable by:

  • NDIN number;
  • ingredient name;
  • name of the party that submitted the notification;
  • date of submission;  
  • and date of FDA’s response.

The information for each NDIN that is available using this website is the same information that is available through FDA’s Division of Dockets Management (Dockets) and at Regulations.gov. However, some of these notifications contain copyrighted material that can only be obtained through a Freedom of Information (FOI) request or viewed in person at the Dockets Public Reading Room. Please see FDA’s FOI website for more information on how to view materials in person or to submit a FOI request.

Note: Any entries without an active link are in the process of being posted on Regulations.gov. Please check back for updates.

Download List of NDINs
1995 to the Present
in XLSX, 190.94 KB / in PDF, 967.43 KB

Recent Updates to the List of NDINs

For your convenience, the following are entries that have recently been updated.

New Dietary Ingredient Notification #Name of New Dietary IngredientFirmDate of SubmissionDate of FDA's Response
1398Astaxanthin-rich carotenoid fermentation productLCY Biosciences, Inc.5/20/20257/28/2025
1402Lacticaseibacillus paracasei subsp. paracasei (or L. paracasei) strain HY7017hy Co., Ltd.5/6/20257/17/25
1403Galangal ExtractTCI Co., Ltd5/14/20257/22/25
1404Lactiplantibacillus plantarum Strain CNCM I-6042Société des Produits Nestlé S.A.5/19/20257/25/25
1406Monomethylsilanetriol stabilized in hydrolyzed fish collagenUSK5/23/20257/3/25
1407Heat-treated culture of Bifidobacterium longum CBi0703BIOSE INDUSTRIE5/27/20257/28/25
1408AEDG PeptideAmritex Inc.5/28/20257/3/25
1409Mangosteen Peel ExtractFytexia6/2/20258/7/25
1410EmmerWheatKMF Co., Ltd.6/13/20257/16/25
1411Tamarind Seed PolysaccharideDEVINTEC SAGL6/13/20258/12/25
1412Porcine kidney protein extract with Diamine Oxidase (DAO)Body Nostrum LLC6/16/20257/29/25
1413Diosmin / Micronized DiosminBordas S.A.6/23/20258/28/25
1414Latilactobacillus curvatus LB-P9LISCure Biosciences Inc.6/27/20259/3/25
1415T-ChOS (proprietary name by Genis hf.)Genis hf.6/30/20259/10/25
1416Benesomno™Nutra-it Inc.6/30/20259/9/25
1417Amanita muscaria mushroom extract (AME-1)Psyched Wellness7/8/20259/18/25
1418Concentrated Nutriterra® Omega-3Nuseed Nutritional US Inc.7/10/20259/19/25
1419Vernonanthura nudiflora extractOSigma Cell & Genetics7/10/20259/19/2025
1420β-Nicotinamide Riboside CitrateShenzhen Nuojiayi Technology CO.,Ltd7/11/20259/23/2025
1421Jatropha macrantha (commonly known as Huanarpo Macho) PowderToro Naturals LLC7/14/20259/22/2025
1422Heri-Mycelium HE12NEW BELLUS ENTERPRISES CO., LTD7/18/20259/26/2025
1423Lactobacillus farraginisepikur international AG7/18/20259/25/2025
1424Muno-IgYIGY Immune Technologies and Life Sciences, Inc.7/23/20259/26/2025
1425Cannabis Sativa L. Essential OilMondays Foods, LLC9/8/202511/21/2025
1426NP-14D Dave's Tinctures7/29/202511/28/2025
1427CHAGADVANCE™ Chaga extractSEPPIC S.A.7/29/20259/30/2025
1428Astragalus extract mixture (HT042) aka Grow HT042NEUMED, Inc.7/30/20259/30/2025
1429Cell-wall Broken Ganoderma Lucidum Spore PowderFujian Xianzhilou Biological Science and Technology Co., Ltd.7/31/20259/30/2025
1430SpirulysatALGOSOURCE8/4/202512/5/2025
1431First Phytoplankton®Phytoplankton Solutions Inc.8/5/202512/4/2025
1432Bovine Gelatin Tannate powder California Greens8/12/202511/28/2025
1433Phaeodactylum tricornutum extract powderMicroalgae Ask Us8/13/202512/3/2025
1434Calcium L-5-Methyltetrahydrofolate (L-5-MTHF-Ca)Wuxi Taxus Pharmaceutical Co., Ltd.8/15/202512/5/2025
1435IMG-1Imagin Pharma8/25/202512/18/2025
1436Full Moon BalanceAphlora Wellness S.A.S.9/2/202512/9/25
1437Lacticaseibacillus rhamnosus HDB1258Hyundai Bioland.Co.,Ltd.9/16/202512/3/25
1438Pasteurized Akkermansia muciniphila HB05P (HB05P®)HealthBiome Inc.9/22/202512/10/25
1439Heat-treated culture of Bifidobacterium longum CBi0703BIOSE INDUSTRIE9/26/202512/3/25
1440Lactiplantibacillus plantarum SKO-001 (AngelaThin)Kolmar BNH Co., LTD.9/30/20251/23/26
1441MaGOmega™Solutex NA, LLC9/30/20251/23/2026
1442Herbal Extract - ShaomaZhijing (T92)Tasly Pharmaceuticals, Inc.11/13/20251/26/2026
1443Heat-Killed (HK) Lactiplantibacillus plantarum beLP1 (beLP1®)Bereum Co., Ltd.11/17/20251/28/2026
1444beta-nicotinamide mononucleotide (β-NMN) or NMNEffepharm, Ltd.11/17/20251/28/2026
1445KorglutideCaregen Co., Ltd.11/17/20251/29/2026
1446VC-H1 (Plant-based collagen alternative)RAWGA Inc.11/18/20251/29/2026
1447Yeast powder IT INTAKE Co.,Ltd.1/30/20264/8/2026
14487-Hydroxymitragynine Shaman Botanicals, LLC11/21/20252/4/2026
1449Pereskia AculeataPhylusbio Inc.11/24/20252/6/2026
1450NPI-001, a Dried Kratom Leaf PowderJohnson Foods11/24/20252/6/2026
1451Reduced Beta-Nicotinamide Mononucleotide, Calcium SaltEffepharm (Shanghai) Co., Ltd.2/11/20264/17/2026
1452Steamed & freeze-dried Mature Silkworm larval Powder 8118 (SMSP 8118)QBM Co., Ltd.12/22/20253/3/2026
1453Ficus Pumila L.Lala’s La’au LLC12/22/20251/15/2026
1454KPFORCEMaruzen Pharmaceuticals Co., Ltd.1/7/20263/18/2026
1455Edible CarbonThe Environment Factory™1/14/20263/18/2026
1456Gelatin tannateCalifornia Greens1/14/20263/25/2026
1457Nutriterra® Total Omega-3Nufarm1/14/20263/26/2026
1458PurInf (I)All Natural Medicine Clinic, LLC1/20/20262/5/2026
1459Rhodiola RoseaPOWER GRID NUTRITION LLC1/20/20264/1/2026
1460Shilajit Fulvic Acid ComplexPOWER GRID NUTRITION LLC1/20/20264/1/2026
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