Science & Research

List of Publications from OWH supported studies

Listed by therapeutic categories:

 
 
 
 
 
 
 
 
 

Autoimmune Diseases

Wiley K, Treadwell E, Manigaba K, Word B, Lyn-Cook B. Ethnic Differences in DNA Methyltransferases Expression in Patients with Systemic Lupus Erythematosus disclaimer icon . J Clin Imm 2013; 33(2):342-348.

Rallabhandi P. Gluten and Celiac Disease - An Immunological Perspective disclaimer icon . J AOAC Int. 2012; 95(2):349-55

Amur S, Parekh A, Mummaneni P. Sex differences and genomics in autoimmune diseases. Journal of Autoimmunity 2012; 38(2-3):J254-J265.

Arasappan D, Tong W, Mummaneni P, Fang H, Amur S. Meta-analysis of microarray data using a pathway-based approach identifies a 37-gene expression signature for systemic lupus erythematosus in human peripheral blood mononuclear cells. BMC Medicine 2011; 9:65.

Dobrovolsky VN, Bucci T, Heflich RH, Desjardins J, Richardson FC. Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease. Molecular Genetics and Metabolism 2003; 78:1–10.

Verthelyi D, Petri M, Ylamus M, Klinman DM. Disassociation of sex hormone levels and cytokine production in SLE patients. Lupus 2001; 10:352-358.

Verthelyi D, Dybdal N, Elias KA, Klinman DM. DNAse treatment does not improve the survival of lupus prone (NZB x NZW) F1 mice. Lupus 1998; 7(4):223-30.

 

Bioinformatic/Data mining/Safety

Colman E, Szarfman A, Wyeth J, Mosholder A, Jillapalli D, Levine J, Avigan M. An evaluation of a data mining signal for amyotrophic lateral sclerosis and statins detected in FDA’s spontaneous adverse event reporting system. Pharmacoepidemiology and Drug Safety 2008; 17:1068–1076.

Szarfman A, Doraiswamy PM, Tonning JM, Levine JG. Association between pathologic gambling and Parkinsonian therapy as detected in the Food and Drug Administration adverse event database. Arch Neurol 2006; 63:299-300.

Szarfman A, Tonning JM, Levine JG, Doraiswamy PM. Atypical antipsychotics and pituitary tumors: a pharmacovigilance study. Pharmacotherapy 2006; 26(6):748–758.

Almenoff J, Tonning JM, Gould AL, Szarfman A, Hauben M, Ouellet-Hellstrom R, Ball R, Hornbuckle K, Walsh L, Yee C, Sacks ST, Yuen N, Patadia V, Blum M, Johnston M, Gerrits C, Seifert H, LaCroix C. Perspectives on the use of data mining in pharmacovigilance. Drug Safety 2005; 28 (11): 981-1007.

Levine J, JMTonning, Szarfman A. Reply: The evaluation of data mining methods for the simultaneous and systematic detection of safety signals in large databases: lessons to be learned. Br J Clin Pharmacol 2005; 61(1):105–113.

Szarfman A,Tonning JM, Doraiswamy PM. Pharmacovigilance in the 21st Century: New Systematic Tools for an Old Problem. Pharmacotherapy 2004; 24(9):1099–1104.

Szarfman A, Machado SG, O’Neil RT. Use of screening algorithms and computer systems to efficiently signal higher-than-expected combinations of drugs and events in the us FDA’s spontaneous reports database. Drug Safety 2002; 25(6):381-392.

Szarfman A, O’Neil RT. Bayesian Data Mining in Large Frequency Tables, with an Application to the FDA Spontaneous Reporting System: Discussion. The American Statistician 1999; 53(3):190-196.

 

Breast Implants

O’Hanlon TP, Lawless OJ, Katzin WE, Feng LJ, Miller FW. Restricted and shared patterns of TCR β-chain gene expression in silicone breast implant capsules and remote sites of tissue inflammation. Journal of Autoimmunity 2000; 14:283–293.

Abbondanzo SL, Young VL, Wei MQ, Miller FW. Silicone gel-filled breast and testicular implant capsules: a histologic and immunophenotypic study. Mod Pathol. 1999; 12(7):706-13.

James SJ, Pogribna M, Miller BJ, Bolon B, Muskhelishvili L. Characterization of cellular response to silicone implants in rats: implications for foreign-body carcinogenesis. Biomaterials 1997 May; 18(9):667-75.

 

Breast Cancer / Mammography

Gu S, Gupta R, Kyprianou I. Computational high-resolution heart phantoms for medical imaging and dosimetry simulations. disclaimer icon Phys. Med. Biol 2011; 56:5845–5864.

Freed M. The effect of protocol parameters on contrast agent washout curve separability in breast DCE-MRI: A simulation study. disclaimer icon Magn. Reson. Med. 2011; 44:544-554.

Freed M, de Zwart JA, Hariharan P, R Myers M, Badano A. Development and characterization of a dynamic lesion phantom for the quantitative evaluation of dynamic contrast-enhanced MRI. Med Phys. 2011; 38(10):5601.

Freed M, Badal A, Jennings RJ, de las Heras H, Myers KJ, Badano A. X-ray properties of an anthropomorphic breast phantom for MRI and x-ray imaging. Phys. Med. Biol 2011; 56 (12):3513–3533.

Badano A, Freed M, Fang Y. Oblique incidence effects in direct x-ray detectors: A first-order approximation using a physics-based analytical model . Med. Phys. Medical Physics 2011; 38(4):2095-98.

Freed M, de Zwart JA, Loud JT, El Khouli RH, Myers KJ, Greene MH, Duyn JH, Badano A. An anthropomorphic phantom for quantitative evaluation of breast MRI. Medical Physics 2011; 38(2):743-53.

Freed M, Park S, Badano A. A fast, angle-dependent, analytical model of CsI detector response for optimization of 3D x-ray breast imaging systems. Medical Physics 2010; 37(6):2593-605.

Park S, Jennings R, Liu H, Badano A, and Myers KJ. A statistical, task-based evaluation method for 3D x-ray breast imaging systems using variable-background phantoms. Medical Physics 2010; 37(12):6253-70.

Athena Starlard-Davenport, Beverly Lyn-Cook, Frederick A. Beland, Igor P. Pogribny. The role of UDP-glucuronosyltransferases and drug transporters in breast cancer drug resistance. Experimental Oncology 2010; 32(3):172-182.

Badal A, Kyprianou IS, Banh DP, Badano A, Sempau J. Penmesh—Monte Carlo radiation transport simulation in a triangle mesh geometry. IEEE Transactions On Medical Imaging 2009; 28(12).

M. Freed, S. Miller, K. Tang, and A. Badano. Experimental validation of Monte Carlo (MANTIS) simulated x-ray response of columnar CsI scintillator screens. Medical Physics 2009; 36(11):4944-56.

Badal A, Kyprianou IS, Badano A, Sempau J. Monte Carlo simulation of a realistic anatomical phantom described by triangle meshes: application to prostate brachytherapy imaging. Radiotherapy And Oncology 2008; 86:99–103.

Kyprianou IS, Badano A, Gallas BD, Myers KJ. Singular value description of a digital radiographic detector: theory and measurements. Med Phys 2008; 35(10):4744-4756.

Badano,A, Kyprianou IS, Jennings RJ. Anisotropic imaging performance in breast tomosynthesis. Med Phys 2007; 34(11):4076-4091.

Brown L, Pennello G. Replacement surgery and silicone gel breast implant rupture: self-report by women after mammoplasty. J of Women’s Health & Gender-Based Med 2002; 11(3).

Barton M, Moore S, Shtatland E, Bright R. The relation of household income to mammography: utilization in a prepaid health care system. J Gen Intern Med 2001; 16:200-203.

Brown L, Pennello G, Berg W, Soo MS, Middleton MS. Silicone gel breast implant rupture, extracapsular silicone, and health status in a population of women. J Rheumatol 2001; 28:996–1003.

Brown L, Middleton MS, Berg W, Soo MS, Pennello G. Prevalence of rupture of silicone gel breast implants revealed on MR imaging in a population of women in Birmingham. Alabama, Am J Roentgenology 2000; 175:1057–1064.

 

Cancer

Wu W., Dokmanovic M.: Trastuzumab. In: Schwab M. (Ed.) Encyclopedia of Cancer: (Book Chapter). SpringerReference. Springer-Verlag Berlin Heidelberg, 2009. DOI: 10.1007/SpringerReference_177618 2012-06-10 09:14:21 UTC

Wang Y, Sung C, Dartois C, Ramchandani R, Booth BP, Rock E, Gobburu J. Elucidation of relationship between tumor size and survival in non-small-cell lung cancer patients can aid early decision making in clinical drug development. Clin Pharmacol Ther 2009; 86(2): 167-174.

Volpe DA, Warren MK. Myeloid clonogenic assays for comparison of the in vitro toxicity of alkylating agents. Toxicology in Vitro 2003; 17:271–277.

Shacter E, Williams JA, Hinson RM, Senturker S, Lee YJ. Oxidative stress interferes with cancer chemotherapy: inhibition of lymphoma cell apoptosis and phagocytosis. Blood 2000; 96:307-313.

 

Cardiovascular Disease

Loring Z, Caños DA, Selzman K, Herz ND, Silverman H, MaCurdy TE, Worrall CM, Kelman J, Richey ME, Piña IL, Strauss DG. Left Bundle Branch Block Predicts Better Survival in Women than Men Receiving Cardiac Resynchronization Therapy: Long Term Follow-Up of 145,000 Patients disclaimer icon . J Am Coll Cardiol HF 2013; 1:237-44.

Loring Z, Strauss D, Gerstenblith G, Tomaselli G, Weiss R, Wu K. Cardiac MRI scar patterns differ by gender in an implantable cardioverter defibrillator and cardiac resynchronization cohort disclaimer icon , Heart Rhythm 2013; 10(5):659–665.

Guo J, Saylor D, Glaser E, Patwardhan D. Impact of artificial plaque composition on drug transport disclaimer icon . J Pharm Sci, 2013; DOI: 10.1002/jps.23537

Loring Z, Chelliah S, Selvester R, Wagner G, Strauss D. A detailed guide for quantification of myocardial scar with the Selvester QRS score in the presence of electrocardiogram confounders disclaimer icon . Journal of Electrocardiology 2011; 44:544–554.

Al- Khatib SM, Calkins H, Eloff BC, Kowey P, Hammill SC, Ellenbogen KA, Marinac-Dabic D, Waldo AL, Brindis R, Wilbur D, Jackman WM, Yaross MS, Russo A, Prystowsky E, Varosy P, Gross T, Pinnow E, Turakhia M, Krucoff MW.
Developing the Safety of Atrial Fibrillation Ablation Registry Initiative (SAFARI) As a Collaborative Pan-Stakeholder Critical Path Registry Model: A Cardiac Safety Research Consortium ‘Incubator’ Think Tank. Am Heart J. 2010 Oct;160(4):619-26

Tavris DR, Shoaibi A, Chen AY, Uchida T, Roe MT, Chen J. Gender differences in the treatment of non–st-segment elevation myocardial infarction. Clin. Cardiol 2010; 33(2):99–103.

Shoaibi A, Tavris DR, McNulty S. Gender differences in correlates of troponin assay in diagnosis of myocardial infarction. Translational Research 2009; 154:250–256.

Finkle J, Bloomfield D, Uhl K, Sanhai W, Stockbridge N, Krucoff MW. New precompetitive paradigms: Focus on cardiac safety. Cardiac Safety Research Consortium Conference Papers 2009.

Douglas PS, Brennan JM, Anstrom KA, Sedrakyan A, Eisenstein EL, Haque G, Dai D, Kong DF, Hammill B, Curtis L, Matchar D, Brindis R, Peterson RD, Clinical Effectiveness of Coronary Stents in Elderly Persons - Results From 262,700 Medicare Patients in the American College of Cardiology–National Cardiovascular Data Registry, J Am C Cardiol 2009; 53(18):1629-41.

Sarapa N, Mortara JL, Brown BD, Isola L,Badilini F. Quantitative performance of e-scribe warehouse in detecting quality issues with digital annotated ECG data from healthy subjects. J Clin Pharmacol 2008; 48:538-546.

Tavris DR, Gallauresi BA, Dey S, Brindis R, Mitchel K. Risk of local adverse events by gender following cardiac catheterization. Pharmacoepidemiology And Drug Safety 2007; 16:125–131.

Katchman AN, Koerner J, Tosaka T, Woosley RL, Ebert SN. Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs. J Pharmacol Exp Ther. Epub 2006; 316:1098–1106.

Tavris DR, Dey S, Gallauresi BA, Brindis RG, Shaw R, Weintraub W, Mitchel K. Risk Of local adverse events following cardiac catheterization by hemostasis device use: phase II. J Invasive Cardiol 2005; 17(12):644-50.

Tavris DR, Gallauresi BA, Lin B, Rich SE, Shaw RE, Weintraub WS, Brindis RG, Hewitt K. Risk of local adverse events following cardiac catheterization by hemostasis device use and gender. J Invasive Cardiol 2004; 16(9):459-64.

Tavris D.R., Gallauresi, B., Rich, S., & Bell, B., Relative risks of reported serious injury and death associated with hemostasis devices by gender. Pharmacoepidemiology and Drug Safety 2003; 12(3):237-241.

Peterson ED, Kaul P, Kaczmarek RG, Hammill BG, Armstrong PW, Bridges CR, Ferguson TB. From controlled trials to clinical practice: monitoring transmyocardial revascularization use and outcomes. J Am Coll Cardiol 2003; 42(9):1611-6.

Rodriguez J, Kilborn MJ, Liu, XK, Pezzullo JC, Woosley RL. Drug-Induced QT prolongation in women during the menstrual cycle. JAMA 2001; 285:1322-1326.

Rieves D, Wright G, Gupta G, Shacter E. Clinical Trial (GUSTO-1 and INJECT) Evidence of Earlier Death for Men than Women After Acute Myocardial Infarction. Am J Cardiol 2000; 85:147–153.

Benton RE, Sale M, Flockhart DA, Woosley RL. Greater quinidine-induced QTc interval prolongation in women. Clin Pharmacol Ther 2000; 67:413-8.

 

Cosmetic / Skin

Stingley RL, Zou W, Heinze TM, Chen HZ, Cerniglia CE. Metabolism of azo dyes by human skin microbiota, Journal of Medical Microbiology 2010; 59:108–114.

Yourick JJ, Jung CT, Bronaugh RL. In vitro and in vivo percutaneous absorption of retinol from cosmetic formulations: Significance of the skin reservoir and prediction of systemic absorption. Toxicol Appl Pharmacol 2008; 231:117–121.

Miller S, Coelho S, Zmudzka B, Beer J. Reduction of the uv burden to indoor tanners through new exposure schedules: a pilot study. Photodermatol Photoimmunol Photomed 2006; 22:59–66.

 

Device Safety

Samore MH, Evans RS, Lassen A, Gould P, Lloyd J, Gardner RM, Abouzelof R, Taylor C, Woodbury DA, Willy M, Bright RA. Surveillance of medical device-related hazards and adverse events in hospitalized patients. JAMA 2004; 291(3):325-34.

 

Dietary Supplements

Wang YJ, Dou JH, Cross KP, Valerio Jr LJ. Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment, of menopausal symptoms. Regulatory Toxicology and Pharmacology 2011; 59(1):111–124.

Nasca MM, Zhou JR, Welty FK. Effect of Soy Nuts on Adhesion Molecules and Markers of Inflammation in Hypertensive and Normotensive Postmenopausal Women.  Am J Cardiol 2008; 102:84-88.

Welty FK, Lee KS, Lew NS, Nasca M, Zhou JR. The association between soy nut consumption and decreased menopausal symptoms. J Women’s Health 2007; 16(3):361-369.

Welty FK, Lee KS, Lew NS, Zhou JR. Effect of soy nuts on blood pressure nd lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women.  Arch Intern Med. 2007; 167:1060-1067.

Anderson GD, Rosito G, Mohustsy MA, Elmer GW. Drug interaction potential of soy extract and Panax ginseng.  J Clin Pharmacol 2003; 43(6):643-8.

Mahady GB, Parrot J, Lee C, Yun GS, Dan A. Botanical dietary supplement use in peri- and postmenopausal women. Menopause 2003; 10(1):65-72.

Burke GI, Legault C, Anthony M, Bland DR, Morgan TM, Naughton MJ, Leggett K, Washburn SA, Vitolins MZ. Soy protein and isoflavone effects on vasomotor symptoms in peri- and postmenopausal women: the Soy Estrogen Alternative Study. Menopause 2003; 10(2):147-153.

 

Feminine Hygiene

Liu H, Gao Y, Yu LR, Jones RC, Elkins CA, Hart ME. Inhibition of Staphylococcus aureus by lysostaphin-expressing Lactobacillus plantarum WCFS1 in a modified genital tract secretion medium. disclaimer icon Appl. Environ. Microbiol 2011; 77:8500-8508.

Elkins CA, Mun˜oz ME, Mullis LB, Stingley RL, Hart ME. Lactobacillus-mediated inhibition of clinical toxic shock syndrome Staphylococcus aureus strains and its relation to acid and peroxide production. Anaerobe 2008; 14:261–267.

Archer JC, Mabry-Smith R, Shojaee S, Threet J, Eckert JJ, Litman VE. Dioxin and furan levels found in tampons. J Womens Health (Larchmt) 2005; 14(4):311-5.

 

HIV

Ragupathy V, Devadas K, Tang S, Wood O, Lee S, Dastyer A, Wang X, Dayton A, Hewlett I. Effect of sex steroid hormones on replication and transmission of major HIV subtypes disclaimer icon . J Steroid Biochem Mol Biol. 2013; 138C:63-71.

Khurana S, Norris PJ, Busch MP, Haynes BF, Park S, Sasono P, Mlisana K, Salim AK, Hecht FM, Mulenga J, Chomba E, Hunter E, Allen S, Nemo G, Rodriguez-Chavez IR, the Women’s Interagency HIV Study Collaborative Study Group, Margolick JB on behalf of Multicenter AIDS Cohort Study (MACS), Golding H. HIV-Selectest Enzyme Immunoassay and Rapid Test: Ability to detect seroconversion following HIV-1 infection. J Clin. Microbiol 2010; 48(1):281–285.

Desai VG, Lee T, Moland CL, Branham WS, Von Tungeln LS, Beland FA, Fuscoe JC. Effect of short-term exposure to zidovudine (AZT) on the expression of mitochondria-related genes in skeletal muscle of neonatal mice. Mitochondrion 2009; 9:9–16.

Zhang M, Huang Q, Huang Y, Wood O, Yuan W, Chancey C, Daniel S, Rios M, Hewlett I, Clouse KA, Dayton AI. Beta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL. Retrovirology 2008; 5:82.

Zubkova I, Mostowski H, Zaitseva M. Up-Regulation of IL-7, stromal-derived factor-1α, thymus-expressed chemokine, and secondary lymphoid tissue chemokine gene expression in the stromal cells in response to thymocyte depletion: implication for thymus reconstitution. J Immunol 2005; 175:2321-23301.

Eller N, Golding H, Inoue S, Beining P, Inman J, Matthews N, Scott DE, Golding B. Systemic and mucosal immunity in rhesus macaques immunized with HIV-1 peptide and gp120 conjugated to Brucella abortus. J Med Primatol 2004; 33(4):167-74.

Bisson G, Gross R, Miller V, Weller I, Walker A, on behalf of the Writing Group. Monitoring of long-term toxicities of HIV treatments: an international perspective. AIDS 2003; 17:2407–2417.

Golding B, Eller N, Levy L, Beining P, Inman J, Matthews N, Scott DE, Golding H. Mucosal immunity in mice immunized with HIV-1 peptide conjugated to Brucella abortus. Vaccine 2002; 20(9-10):1445-50.

Lapham CK, Zaitseva MB, Lee S, Romanstseva T, Golding H. Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5. Nat Med. 1999; 5(3):303-8. Erratum in: Nat Med 1999; 5(5):590.

Scott DE, Golding H, Huang LY, Inman J, Golding B. HIV peptide conjugated to heat-killed bacteria promotes antiviral responses in immunodeficient mice. Aids Research And Human Retroviruses 1998; 14(14):1263-1269.

Robbins PA, Roderiquez GL, Peden KW, Norcros MA. Human Immunodeficiency Virus Type 1 Infection of Antigen-Specific CD4 Cytotoxic T Lymphocytes. AIDS Research And Human Retroviruses 1998; 14(16):1397-1406.

Zoeteweij JP, Golding H, Mostowski H, Blauvelt A. Cutting edge: Cytokines regulate expression and function of the HIV coreceptor CXCR4 on human mature dendritic cells. J Immunol 1998; 161:3219-3223.

Zaitseva MB, Lee S, Rabin RL, Tiffany HL, Farber JM, Peden KW, Murphy FM, Golding H. CXCR4 and CCR5 on Human Thymocytes: Biological Function and Role in HIV-1 Infection. J Immunol 1998; 161:3103-3113.

Roderiquez G, Oravecz T, Yanagishita M, Bou-Habib DC, Mostowski H, Norcross MA. Mediation of human immunodeficiency virus type 1 binding by interaction of cell surface heparan sulfate proteoglycans with the V3 region of envelope gp120-gp41. J Virol 1995; 69(4):2233-9.

Bou-Habib DC, Roderiquez G, Oravecz T, Berman PW, Lusso P, Norcross MA. Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization. J Virol 1994; 68(9):6006-13.

 

Hormone / Endocrine Disruptors

Slavov S, Geesaman E, Pearce B, Schnackenberg L, Buzatu D, Wilkes J, Beger R. 13C NMR−Distance Matrix Descriptors: Optimal Abstract 3D Space Granularity for Predicting Estrogen Binding disclaimer icon . J. Chem. Inf. Model 2012; 52 (7):1854–1864.

RD Wagner, SJ Johnson. Probiotic lactobacillus and estrogen effects on vaginal epithelial gene expression responses to Candida albicans disclaimer icon . J Biological Science 2012; 19:58.

RD Wagner, SJ Johnson, DR Tucker. Protection of Vaginal Epithelial Cells with Probiotic Lactobacilli and the Effect of Estrogen Against Infection by Candida albicans. disclaimer icon J Med Microbiology 2012; (in press)

Matthews EJ, Kruhlak NL, Benz RD, Ivanov J, Klopman G, Contrera JF. A comprehensive model for reproductive and developmental toxicity hazard identification: II. Construction of QSAR models to predict activities of untested chemicals. Regulatory Toxicology and Pharmacology 2007: 47:136–155.

Matthews EJ, Kruhlak NL, Benz RD, Contrera JF. A comprehensive model for reproductive and developmental toxicity hazard identification: I. Development of a weight of evidence QSAR database. Regulatory Toxicology and Pharmacology 2007; 47:115–135.

Verthelyi D, Klinman DM. Sex hormone levels correlate with the activity of cytokine-secreting cells in vivo. Immunology 2000; 100: 384-390.

Verthelyi D. Sex hormones as immunomodulators in health and disease. Inter Immunopharmacology 2001; 1:983–993.

Verthelyi D. Female’s Heightened Immune Status: Estrogen, T Cells, and Inducible Nitric Oxide Synthase in the Balance. Endocrinology 2006; 147(2):659–661.

Branham WS, Fishman R, Streck RD, Medlock KL, De George JJ, Sheehan DM. ICI 182,780 inhibits endogenous estrogen-dependent rat uterine growth and tamoxifen-induced developmental toxicity. Biol Reprod 1996; 54(1):160-7.

Medlock KL, Branham WS, Sheehan DM. Effects of toremifene on neonatal rat uterine growth and differentiation. Biol Reprod 1997 May; 56(5):1239-44.

Beland FA, McDaniel LP, Marques MM. Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo. Carcinogenesis 1999; 20(3):471–477.

Marques MM, Beland FA. Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide. Carcinogenesis 1997;18(10):1949–1954.

Tong W, Perkins R, Xing L, Welsh WJ, Sheehan DM. QSAR models for binding of estrogenic compounds to estrogen receptor alpha and beta subtypes. Endocrinology 1997; 138(9):4022-5.

Tong W, Perkins R, Strelitz R, Collantes ER, Keenan S, Welsh WJ, Branham WS, Sheehan DM. Quantitative structure-activity relationships (QSARs) for estrogen binding to the estrogen receptor: predictions across species. Environ Health Perspect 1997; 105(10):1116-24.

Blair RM, Fang H, Branham WS, Hass BS, Dial SL, Moland CL, Tong W, Shi L, Perkins R, Sheehan DM. The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands. Toxicol Sci 2000; 54(1):138-53.

Fang H, Tong W, Perkins R, Soto AM, Prechtl NV, Sheehan DM. Quantitative comparisons of in vitro assays for estrogenic activities. Environ Health Perspect 2000; 108(8):723-9.

Tong W, Lowis DR, Perkins R, Chen Y, Welsh WJ, Goddette DW, Heritage TW, Sheehan DM. Evaluation of quantitative structure-activity relationship methods for large-scale prediction of chemicals binding to the estrogen receptor. J Chem Inf Comput Sci. 1998; 38(4):669-77.

Shi L, Tong W, Fang H, Xie Q, Hong H, Perkins R, Wu J, Tu M, Blair RM, Branham WS, Waller C, Walker J, Sheehan DM. An integrated "4-phase" approach for setting endocrine disruption screening priorities--phase I and II predictions of estrogen receptor binding affinity. SAR QSAR Environ Res 2002; 13(1):69-88.

Xing L, Welsh WJ, Tong W, Perkins R, Sheehan DM. Comparison of estrogen receptor alpha and beta subtypes based on comparative molecular field analysis (CoMFA). SAR QSAR Environ Res 1999; 10(2-3):215-37.

Tolleson WH, Doerge DR, Churchwell MI, Marques MM, Roberts DW. Metabolism of biochanin A and formononetin by human liver microsomes in vitro. J Agric Food Chem 2002; 50(17):4783-90.

Lavigne JA, Goodman JE, Fonong T, Odwin S, He P, Roberts DW, Yager JD. The Effects of Catechol-O-Methyltransferase Inhibition on Estrogen Metabolite and Oxidative DNA Damage Levels in Estradiol-treated MCF-7 Cells. Cancer Research 2001;61: 7488–7494.

Aidoo A, Shelton SD, Lyn-Cook LE, Chen T, Manjanatha MG. Effects of Daidzein, Genistein, and 17β-Estradiol on 7,12-Dimethylbenz[a]anthracene-Induced Mutagenicity and Uterine Dysplasia in Ovariectomized Rats. Nutrition and Cancer 2005; 53(1):82-90.

Manjanatha MG, Shelton SD, Bishop ME, Lyn-Cook LE, Aidoo A. Dietary effects of soy isoflavones daidzein and genistein on 7,12-dimethylbenz[a]anthracene-induced mammary mutagenesis andcarcinogenesis in ovariectomized Big Blue® transgenic rats. Carcinogenesis 2006; 27(12):2555–2564.

Leighton JK, Wei LL. Progesterone receptor and Development. Book chapter in Hormones and growth factors in development and neoplasia 1998.

 

Infant Feeding

Fein SB, Grummer-Strawn LM, Raju TNK. Infant feeding and care practices in the United States: results from the infant feeding practices Study II. Pediatrics 2008; 122:S25-S27.

Fein SB, Labiner-Wolfe J, Shealy KR, Li R, Chen J, Grummer-Strawn LM. Infant feeding practices Study II: study methods. Pediatrics 2008; 122:S28-S35.

Grummer-Strawn LM, Scanlon KS, Fein SB. Infant feeding and feeding transitions during the first year of life. Pediatrics 2008; 122:S36-S42.

Labiner-Wolfe J, Fein SB, Shealy KR. Infant formula–handling education and safety. Pediatrics 2008; 122:S85-S90.

Fein SB, Labiner-Wolfe J, Scanlon KS, Grummer-Strawn LM. Selected complementary feeding practices and their association with maternal education. Pediatrics 2008; 122:S91-S97.

Scariati PD, Grummer-Strawn LM, Fein SB, Yip R. Risk of Diarrhea Related to Iron Content of Infant Formula: Lack of evidence to support the use of low-iron formula as a supplement for breastfed infants. Pediatrics 1997; 99(3):e2.

 

Osteoporosis and Bone Health

Wear KA, Garra BS. Assessment of bone density using ultrasonic backscatter. Ultrasound In Med. & Biol 1998; 24(5): 689–695.

Wear KA, Stuber AP, Reynolds JC. Relationships of ultrasonic backscatter with ultrasonic attenuation, sound speed and bone mineral density in human calcaneus. Ultrasound In Med. & Biol 2000; 26(8):1311–1316.

Wear KA. Measurements of phase velocity and group velocity in human calcaneus. Ultrasound In Med. & Biol 2000; 26(4):641–646.

Wear KA. Temperature dependence of ultrasonic attenuation in human calcaneus. Ultrasound In Med. & Biol 2000; 26(3):469–472.

Wear KA. Characterization of trabecular bone using the backscattered spectral centroid shift. IEEE Transactions on Ultrasonics, Ferroflectrics, and Frequency Control 2003; 50(4).

Wear KA. Measurement of dependence of backscatter coefficient from cylinders on frequency and diameter using focused transducers – with applications in trabecular bones. J Of Acoustical Society Of America 2004; 115(1): 66-72.

Wear KA. Relationships among calcaneal backscatter, attenuation, sound speed, hip bone mineral density, and age in normal adult women. J Of Acoustical Society Of America, 2001; 110(1): 573-8.

Wear KA, Laib A. The dependence of ultrasonic backscatter on trabecular thickness in human calcaneus: theoretical and experimental results. IEEE Trans Ultrason Ferroelectr Freq Control 2003; 50(8):979-86.

Wear KA. Frequency dependence of ultrasonic backscatter from human trabecular bone: theory and experiment. J Acoust Soc Am 1999; 106(6):3659-64.

Graham J, Ahn C, Hai N, Buch BD. Effect of bone density on vertebral strength and stiffness after percutaneous vertebroplasty. Spine 2007; 32(18):E505–E511.

 

Pregnancy

James H. Fischer, Gloria E. Sarto, Mitra Habibi, Sarah J. Kilpatrick, Ruth E. Tuomala, Janice M. Shier, Lori Wollett, Patricia A. Fischer, Kinnari S. Khorana and Keith A. Rodvold. Influence of Body Weight, Ethnicity, Oral Contraceptives, and Pregnancy on the Pharmacokinetics of Azithromycin in Women of Childbearing Age. Antimicrob. Agents Chemother. 2012; 56(2):715-724.

Trapnell CB, Donahue SR, Collins JM, Flockhart DA, Thacker D, Abernethy DR. Thalidomide does not alter the pharmacoltinetics of ethinyl estradiol and norethindrone. Clin Pharmacol Ther 1998; 64:597-602.

Felix RJ, Jones KL, Johnson KA, McCloskey CA, Chambers CD for the Organization of Teratology Information Services (OTIS) Collaborative Research Group. Postmarketing surveillance for drug safety in pregnancy: the organization of teratology information services project. Birth Defects Research (Part A). 2004; 70:944–947.

Gorski JC, Huang SM, Pinto A, MD, Hamman MA, Hilligoss JK, Zaheer NA, Desai M, Miller M, Hall SD. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther 2004; 75:89-100.

Sprando RL, Collins TFX, Black TN, Olejnik N, Grundel E, Ruggles DI. Effects of androstenedione on in utero development in rats. Food Chem Toxicol 2004; 42:917–924.

Sahu SC, Sapienza PP, Sprando RL, Collins TF, Ross IA, Flynn TJ, Wiesenfeld PL, O'Donnell MW, Kim CS. Hepatotoxicity of androstenedione in pregnant rats. Food Chem Toxicol 2005; 43(2):341-344.

Sprando RL, Collins TF, Black TN, Olejnik N, Sapienza P, Ramos-Valle M, Ruggles DI. Maternal exposure to androstenedione does not induce developmental toxicity in the rat. Food Chem Toxicol 2005; 43(4):505-513.

Flynn TJ, Sapienza PP, Wiesenfeld PW, Ross IA, Sahu S, Kim CS, O'Donnell MW Jr, Collins TF, Sprando RL. Effects of oral androstenedione on steroid metabolism in liver of pregnant and non-pregnant female rats. Food Chem Toxicol 2005; 43(4):537-542.

Wiesenfeld PW, Sapienza PP, Flynn TJ, Ford CE, Ross IA, Sahu S, Kim CS, O'donnell MW Jr, Collins TF, Sprando RL. Effects of oral androstenedione on phospholipid fatty acids, ATP, caspase-3, prostaglandin E(2) and C-reactive protein in serum and livers of pregnant and non-pregnant female rats. Food Chem Toxicol 2006; 44:579-587.

Kim CS, Ross IA, Sprando RL, Johnson WD, Sahu SC, Flynn TJ, Wiesenfeld PL, Collins TFX, O’Neilll RK, Sapienza P. Distribution of androstenedione and its effects on total free fatty acids in pregnant rats. Toxicol Ind Health 2007; 23: 65–74.

James SJ, Pogribna M, Pogribny IP, Melnyk S, Hine RJ, Gibson JB, Yi P, Tafoya DL, Swenson DH, Wilson VL, Gaylor DW. Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am J Clin Nutr 1999; 70(4):495-501.

Hobbs CA, Sherman SL, Yi P, Hopkins SE, Torfs CP, Hine RJ, Pogribna M, Rozen R, James SJ. Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome. Am J Hum Genet 2000; 67(3):623-30. Epub 2000 Aug 7.

Idowu OR, Peggins JO, Cullison R, von Bredow J. Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin. Research in Veterinary Science 2010.

Hall SD, Wang Z, Huang SM, Hamman MA, Vasavada N, Adigun AQ, Hilligoss JK, Miller M, Gorski JC. The interaction between St John's wort and an oral contraceptive. Clin Pharmacol Ther 2003; 74(6):525-35.

Andrew MA, Easterling TR, Carr DB, Shen D, Buchanan ML, Rutherford T, Bennett R, Vicini P, Hebert MF. Amoxicillin pharmacokinetics in pregnant women: Modeling and simulations of dosage strategies. Clin Pharmacol Ther 2007; 81(4):547-556.

Hebert MF, Carr DB, Anderson GD, Blough D, Green GE, Brateng DA, Kantor E, Benedetti TJ, Easterling TR. Pharmacokinetics and pharmacodynamics of atenolol during pregnancy and postpartum. J Clin Pharmacol 2005; 45(1):25-33.

Freeman MP. Bipolar Disorder and Pregnancy: Risks Revealed. Am J Psychiatry 2007; 164(12):1171-1173.

Freeman MP, Nolan PE, Davis MF, Anthony M, Fried K, Fankhauser M, Woosley RL, Moreno F. Pharmacokinetics of Sertraline Across Pregnancy and Postpartum. J Clin Psychopharmacol 2008; 28:646–653.

Eyal S, Kim JD, Anderson GD, Buchanan ML, Brateng DA, Carr D, Woodrum DE, Easterling TR, Hebert MF. Atenolol pharmacokinetics and excretion in breast milk during the first 6 to 8 months postpartum. J Clin Pharmacol 2010.

Cooper WO, Hickson GB, Ray WA. Prescriptions for contraindicated category X drugs in pregnancy among women enrolled in TennCare. Pediatric and Perinatal Epidemiology 2004;18:106–111.

Cooper WO, Willy WE, Pont SJ, Ray WA. Increasing use of antidepressants in pregnancy. Am J Obstet Gynecol 2007; 196:544.e1-544.e5.

Enriquez R, Griffin MR, Carroll KN, Wu P, Cooper WO, Gebretsadik T, Dupont WD, Mitchel EF, Hartert TV. Effect of maternal asthma and asthma control on pregnancy and perinatal outcomes. J Allergy Clin Immunol 2007; 120:625-30.

 

Sex Differences

Z Loring, D Strauss, G Gerstenblith, G Tomaselli, R Weiss, K Wu. Cardiac MRI scar patterns differ by gender in an implantable cardioverter defibrillator and cardiac resynchronization cohort. Heart Rhythm 2013 (in press).

Flynn TJ, Ferguson MS. An in vitro system for studying potential biological mechanisms of human sex differences in susceptibility to acute liver injury. Toxicology Letters 2010; 198: 232–236.

Paine MF, Ludington SS, Chen ML, Stewart PW, Huang SM, Watkins PB. Do men and women differ in proximal small intestinal CYP3a or p-glycoprotein expression? Drug Metabolism And Disposition 2005; 33(3):426–433

Delongchamp RR, Velasco C, Dial S, Harris AJ. Genome-wide estimation of gender differences in the gene expression of human livers: Statistical design and analysis. BMC Bioinformatics 2005; 6(2):S13.

 

Sexually Transmitted Disease

Batditch-Crovo P, Witter F, Hamzeh F, McPherson J, Stratton P, Alexander NJ, Trapnell CB. Quantitation of vaginally administered nonoxynol-9 in premenopausal women. Contraception 1997; 55:261-263

Thompson DK, Deal CD, Ison CA, Zenilman JM, Bash MC. A typing system for neisseria gonorrhoeae based on biotinylated oligonucleotide probes to pib gene variable regions. J Infect Dis 2000; 181:1652–60.

McKnew DL, Lynn F, Zenilman JM, Bash MC. Porin variation among clinical isolates of Neisseria gonorrhoeae over a 10-year period, as determined by Por variable region typing. J Infect Dis 2003; 187(8):1213-22.

Bash MC, Zhu P, Gulati S, McKnew D, Rice PA, Lynn F. por Variable-region typing by DNA probe hybridization is broadly applicable to epidemiologic studies of Neisseria gonorrhoeae. J Clin Microbiol 2005; 43(4):1522-30.

Methta RI, Lytle CD, Thomas DP, Myers MR. Cause of cessation of viral passage through artificially-induced holes in latex condoms. Journal of Rubber Research 1998; 1(1):1-13.

Myers MR, Lytle CD, Routson LB. A mathematical model for stimulating virus transport through synthetic barriers. Bulletin of Mathematical Biology 1999; 61:113-140.

Kaplan DA, Lytle CD, Routson LB, Myers MR. Issues associated with using fluorescent microspheres to evaluate the barrier integrity of natural rubber latex films. Journal Of Rubber Research 1999;2(3):131-139.

Myers MR, Lytle CD, Routson LB. Virus adsorption within pores in latex:  assessment of reversibility effects. Aiche Journal 2000; 46(9):1894-1896.

Myers MR. Calculation of brownian particle transmission in long, wide channels. Aiche Journal 2001; 47(2):250-255.

Myers MR, Das B. Virus transmission through compromised synthetic barriers: part I--effect of unsteady driving pressures. J Biomech Eng. 2001; 123(5):506-12.

Das B, Myers MR. Virus transmission through compromised synthetic barriers: part II--influence of pore geometry. J Biomech Eng. 2001; 123(5):513-8.

Kerr LN, Boivin WS, Hamilton SL, Mailhot SA, O’Malley LG, Boyd SM, Pierdominici VJB, Bushar HF. Comparison of ISO/FDA and ASTM condom water leak test method. J Testing and Evaluation 2001; 29(2):192-198.

Kerr LN, Mailhot SA, Boivin WS, Hamilton SL, O’Malley LG, Boyd SM, Pierdominici VJB, Bushar HF. Use of Surfactants in Condom Water Leak Testing. J Testing and Evaluation 2002; 30(4)313–321.

 

Women in Clinical Trials

G Soon, M Min, K Struble, K Chan-Tack, T Hammerstrom, K Qi, S Zhou, R Bhore, J Murray, D Birnkrant, Meta-Analysis of Gender Differences in Efficacy Outcomes for HIV-Positive Subjects in Randomized Controlled Clinical Trials of Antiretroviral Therapy (2000–2008). disclaimer icon AIDS Patient Care and STDs 2012; 26(8):444-453

Yang Y, Carlin AS, Faustino PJ, Paga´n Motta MI, Hamad ML, He R, Watanuki Y, Pinnow EE, Khan MA, Participation of Women in Clinical Trials for New Drugs Approved by the Food and Drug Administration in 2000–2002. J of Women’s Health 2009; 18(3):303-310

 

Other

Minjun Chen, Vikrant Vijay, Qiang Shi, Zhichao Liu, Hong Fang, Weida Tong. FDA-approved drug labeling for the study of drug-induced liver injury. Drug Discov Today 2011; 16(15-16):697-703.

Florian JA, Tornøe CW, Brundage R, Parekh A, Garnett CE, Population Pharmacokinetic and Concentration–QTc Models for Moxifloxacin: Pooled Analysis of 20 Thorough QT Studies, J Clin Pharmacol 2011; 51(8):1152-1162.

Knapp PE, Showers KM, Phipps JC, Speckman JL, Sternthal E, Freund KM, Ash AS, Apovian CM. Self-Monitoring of blood glucose with finger tip versus alternative site sampling: effect on glycemic control in insulin-using patients with type 2 diabetes. Diabetes Tech Ther 2009; 11(4):219-225.

Warfel JM, D’Agnillo F. Anthrax Lethal Toxin Enhances TNF-Induced Endothelial VCAM-1 Expression via an IFN Regulatory Factor-1-Dependent Mechanism. J Immunol 2008; 180:7516-75241.

Blakely S, Herbert A, Collins M, Jenkins M, Mitchell G, Grundel E, O’Neill KR, Khachik F. Lutein interacts with ascorbic acid more frequently than with α-tocopherol to alter biomarkers of oxidative stress in female zucker obese rats. J. Nutr 2003; 133:2838–2844.

Pogribna M, Melnyk S, Pogribny I, Chango A, Yi P, James SJ. Homocysteine Metabolism in Children with Down Syndrome: In Vitro Modulation. Am J Hum Genet 2001; 69(1):88–95.

Melnyk S, Pogribna M, Pogribny IP, Yi P, James SJ. Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5'-phosphate concentrations. Clin Chem. 2000; 46(2):265-72. Erratum in: Clin Chem 2001; 47(3):612.

Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 2000; 275(38):29318-23.

Melnyk S, Pogribna M, Pogribny I, Hine RJ, James SJ. A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection. J Nutr Biochem 1999; 10(8):490-7.

 

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