Science & Research

Bioinformatics Tools

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The National Center for Toxicological Research conducts research in both bioinformatics and chemoinformatics. The Center also develops and coordinates bioinformatics capabilities within NCTR, across FDA Centers, and in the larger toxicology community. These Bioinformatics Tools were created at NCTR with the goal of developing methods for the analysis and integration of complex omics (genomics, transcriptomics, proteomics, and metabolomics) datasets. The list of Bioinformatics Tools are listed below:

  • ArrayTrack™
    DNA microarray data management, mining, analysis, and interpretation software
  • atBioNet
    Integrated PPI (protein-protein interaction) Network Analysis Tool for Systems Biology and Biomarker Discovery
  • Decision Forest
    Novel pattern-recognition method for analysis of data from microarray experiments, proteomics research, and predictive toxicology
  • Estrogenic Activity Database (EADB)
    Comprehensive set of estrogenic activity data from a variety of data sources and a component of the enhanced Endocrine Disruptors Knowledge Base (EDKB) 
  • Endocrine Disruptor Knowledge Base (EDKB)
    Scientific resources for estrogen and androgen activity of potetial endocrine disruptor chemicals
  • FDALabel
    Full-Text Search of Drug Label Database
  • Gene Ontology for Functional Analysis (GOFFA)
    ArrayTrack™ tool to identify terms in Gene Ontology associated with a list of genes
  • Liver Toxicity Knowledge Base (LTKB)
    Collection of diverse drug-induced liver injury data associated with individual drugs and development of predictive models to assess risk of drug-induced liver injury
  • MicroArray Quality Control (MAQC)
    Project to develop microarray quality control metrics and thresholds
  • Mold2 
    Software that generates molecular descriptors from two-dimensional structures
  • NCTR Liver Cancer Database (NCTRlcdb)
    Database of 999 chemicals with assigned liver-toxicity classifications to facilitate the construction of cleaner and better carcinogenicity models by FDA and other organizations  
  • SNPTrack
    Integrated solution for the management, analysis, and interpretation of genetic association study data
     

 

Contact FDA

870-543-7000
National Center for Toxicological Research

Food and Drug Administration

3900 NCTR Road

Jefferson, AR 72079

Page Last Updated: 10/31/2014
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