NCTR Research Highlights
Current Highlight from March 7, 2014
Pathogenesis and Host Adaptability of Salmonella
Scientists from NCTR, the University of Minnesota, and the University of Arkansas have published a review article in Microbiology and Molecular Biology Reviews that examines how Salmonella serotypes adapt to hosts and may cause human disease through consumption of contaminated poultry and eggs. The article addresses how the acquisition or loss of bacterial genes can potentially impact the range of hosts that Salmonella can infect. Additional factors that affect the ability of Salmonella to colonize a host species and cause disease include: the host’s immune system, specific pathogen responses, the host environment, and intestinal microbiota. An in-depth understanding of the mechanisms of Salmonella pathogenesis is essential for the development of better strategies for intervention and treatment in animals and humans.
For additional information, please contact Steven Foley, Ph.D., and Rajesh Nayak, Ph.D., Division of Microbiology, FDA/NCTR.