About FDA

NCTR Research Highlights

Red envelope icon for GovdeliveryGet e-mail updates when this information changes.


Current Highlight from February 13, 2015

Physiologically Based Pharmacokinetic (PBPK) Modeling of Bisphenol A (BPA)

NCTR scientists published a review article in Frontiers in Pharmacologydisclaimer icon that focused on the rationale and utilization of various NCTR-conducted BPA studies across species (rodents, nonhuman primates), life stages (adults, infants), and routes of administration (intravenous, oral) to construct the BPA PBPK model.  The authors also discuss important aspects related to gastrointestinal metabolism of BPA, as well as biliary excretion, enterohepatic recirculation, and renal reabsorption of BPA conjugates.  The use of computational modeling, to quantitatively understand the processes that drive the pharmacokinetics of BPA in different species and life stages, increases confidence in the extrapolation of animal studies to humans and in the interpretation of human biomonitoring data. 

For additional information, please contact Jeffrey Fisher, Ph.D., Division of Biochemical Toxicology, FDA/NCTR.

 

Contact FDA

870-543-7000
National Center for Toxicological Research

Food and Drug Administration

3900 NCTR Road

Jefferson, AR 72079

Page Last Updated: 02/20/2015
Note: If you need help accessing information in different file formats, see Instructions for Downloading Viewers and Players.