NCTR Research Highlights
Current Highlight from April 24, 2015
Effects of Orally Administered BPA on Gene Expression in Prostate and Female Mammary Glands of Rats
NCTR scientists reported that no apparent dose-related gene expression or epigenetic effects were detected in prostates or female mammary glands from rat pups that were daily administered BPA across a wide range of doses below the no-adverse-effect level currently used by the FDA. However, a BPA dose of 500,000 times the mean human-exposure level induced gene-expression changes that overlapped partially with those induced by ethinyl estradiol (reference estrogen control), suggesting that BPA has some estrogenic potential at this high dose. These results are consistent with previously reported toxicology endpoints from the same study. This study was conducted at NCTR under the auspices and funding of the Interagency Agreement between FDA/NCTR and NIEHS/NTP. A manuscript describing this study is available online at Food and Chemical Toxicology.
For additional information, please contact Luisa Camacho, Ph.D., or Barry Delclos, Ph.D., Division of Biochemical Toxicology, FDA/NCTR.
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