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NCTR Research Highlights

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Current Highlight from February 13, 2015

Physiologically Based Pharmacokinetic (PBPK) Modeling of Bisphenol A (BPA)

NCTR scientists published a review article in Frontiers in Pharmacologydisclaimer icon that focused on the rationale and utilization of various NCTR-conducted BPA studies across species (rodents, nonhuman primates), life stages (adults, infants), and routes of administration (intravenous, oral) to construct the BPA PBPK model.  The authors also discuss important aspects related to gastrointestinal metabolism of BPA, as well as biliary excretion, enterohepatic recirculation, and renal reabsorption of BPA conjugates.  The use of computational modeling, to quantitatively understand the processes that drive the pharmacokinetics of BPA in different species and life stages, increases confidence in the extrapolation of animal studies to humans and in the interpretation of human biomonitoring data. 

For additional information, please contact Jeffrey Fisher, Ph.D., Division of Biochemical Toxicology, FDA/NCTR.


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Page Last Updated: 02/20/2015
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