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VCU TCORS Project 2: Using User Behavior Data Collected in the Clinical Lab to Test Hypotheses about Advanced-generation ECIGs and Generate Population-level Predictions Regarding Potential Regulatory Action

Principal Investigator(s): Alison Breland

Funding Mechanism: National Institutes of Health – TCORS Grant

ID number: 2 U54 DA036105-06

Award Date: 8/28/18

Institution: Virginia Commonwealth University


E-cigarette nicotine delivery, user subjective response, and user behavior measures (such as puff topography) can be assessed using rigorously-controlled, well-established clinical laboratory methods. The goal of this project is to use these established clinical laboratory methods to examine the extent to which e-cigarette nicotine delivery, e-cigarette liquid consumption, subjective response, and puff topography are influenced by manipulations of e-cigarette liquid nicotine concentration and device power, nicotine flux, and flavor availability. Study aims are: (1) to manipulate e-cigarette liquid nicotine concentration and device power to evaluate how nicotine delivery, abstinence suppression, and e-cigarette liquid consumption change as nicotine concentration is lowered, and whether these changes are offset by higher power; (2) to manipulate nicotine flux to determine whether nicotine delivery and abstinence suppression are related directly to flux; and (3) to manipulate e-cigarette liquid flavors to determine whether nicotine delivery, abstinence suppression, and e-cigarette liquid consumption vary by flavor for e-cigarette users and for smokers. The three aims correspond to three independent studies, each involving exclusive e-cigarette users and non-e-cigarette-using cigarette smokers (ages 18-55).  This project will assess the nicotine delivery and subjective response profile of e-cigarettes, will generate new data regarding the effects of advanced-generation e-cigarettes on user behavior, and will contribute to population-level predictions.


VCU TCORS: Center for the Study of Tobacco Products Related Resources