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Understanding Tobacco Flavor Effects on Waterpipe Smokers' Experiences and Exposures

Understanding Tobacco Flavor Effects on Waterpipe Smokers' Experiences and Exposures

Principal Investigator: Wasim Maziak

Funding Mechanism: National Institutes of Health – Grant

ID number: 1R01DA042477-01

Award Date: 8/15/2016

Institution: Florida International University


Waterpipe tobacco smoking is increasing rapidly in the U.S., particularly among youth and young adults. Evidence suggests that waterpipe smoking can lead to addiction, cigarette smoking, and known smoking-related diseases including cancer, cardiovascular disease and adverse pregnancy outcomes. The goal of this study is to evaluate the impact of flavorings on nicotine delivery, toxicant exposure, dependence, and smoking behavior. This will be evaluated in a clinical laboratory study including beginning as well as established waterpipe smokers. The study will compare how smoking unflavored waterpipe tobacco compares to preferred flavored brand in terms of smokers’ exposure to nicotine, puffing behaviors, subjective measures of satisfaction, and suppression of withdrawal and craving. Researchers will recruit two groups of waterpipe smokers aged 18-30) based on their use frequency: 72 low frequency smokers (beginners) and 72 high frequency (experienced) smokers. All subjects will participate in two waterpipe smoking sessions that differ by flavor (preferred flavor; unflavored). Study aims are: (1) to examine the influence of flavor manipulation on subjective/dependence responses among beginning and experienced waterpipe smokers: (2) to examine the influence of flavor manipulation on nicotine delivery among beginning and experienced waterpipe smokers; and (3) to examine the effect of flavor on smoking behavior (puff topography) and toxicant exposure among beginning and experienced waterpipe smokers.