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UMD TCORS: Toxicity Testing of New and Manipulated Tobacco Products

Principal Investigator: Courtney Granville

Funding Mechanism: National Institutes of Health- TCORS Grant

ID number: 1P50CA180523-01

Award Date: 9/18/2013

Institution: Battelle Centers


Traditional test methods used to classify cigarette smoke by determining tar, nicotine, and carbon monoxide (CO) yields per cigarette do not account for differences in user behavior. Measuring actual exposures experienced by most tobacco users is critical to understanding differences in harmful and potentially harmful constituents (HPHCs) in the many tobacco product types and brands available. This project will characterize the chemical profiles and physical properties of combustible, noncombustible, conventional, new, emerging, and manipulated tobacco products (e.g., cigarettes, electronic cigarettes, smokeless tobacco, little cigars, waterpipes, snus, and dissolvables). Using within-subject crossover acute laboratory trials and an established boost method paradigm in 72 subjects (aged 18 and older), investigators will measure subjects’ relative exposures to HPHCs (via puff topography, exhaled breath particle size distribution, and chemical analysis of blood and saliva samples) from new and manipulated tobacco products. Specific aims are: (1) to determine effects of combustible tobacco products designed for consumer inhalation (i.e., standard cigarettes, electronic cigarettes) on toxicity and uptake of select HPHCs; and (2) to determine effects of smokeless tobacco products (including dissolvables) designed for buccal absorption on toxicity and uptake of select HPHCs. This study will further inform the FDA's ongoing efforts to identify and measure the tobacco product toxins that directly contribute to the risk of tobacco-related disease.


Rapid Response Characterization of New and Manipulated Tobacco Products (TCORS) Related Resources