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UCSF TCORS: Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products

Principal Investigator: Peter Ganz and Suzaynn Schick

Funding Mechanism: National Institutes of Health- TCORS Grant

ID number: 1P50CA180890-01

Award Date: 9/19/2013

Institution: University of California San Francisco

The cardiovascular risks of secondhand cigarette smoke, smokeless tobacco (i.e., moist snuff), and e-cigarettes are not adequately understood. This project, a cardiovascular assessment of the effects of tobacco and nicotine, will involve controlled short-term exposures of 88 adult smokers and nonsmokers (aged 21-50) to test products that provide a wide range of nicotine, particle and other cardiovascular toxin concentrations to determine how these components adversely affect cardiovascular risk. Assessment methods will include flow-mediated dilation, heart rate measurement, thromboelastography, Doppler testing, digital vasoconstriction testing, peripheral arterial tonometry, and blood biomarker measurement, and others. Specific aims are: (1) to determine the relative contributions of nicotine and combustion products to the cardiovascular risk associated with active cigarette smoking; (2) to determine which cardiovascular risk biomarkers are affected by exposure to low concentrations of other constituents and secondhand smoke; (3) to determine the cardiovascular risk of smokeless tobacco use; and (4) to determine the cardiovascular risk of electronic cigarettes and the respective contributions of nicotine and electronic cigarette vapor. New biomarkers that can detect differences in the cardiovascular safety of various tobacco products may help inform FDA regulation of conventional, new and emerging products.

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