UCSF TCORS: Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products
Principal Investigator: Peter Ganz and Suzaynn Schick
Funding Mechanism: National Institutes of Health- TCORS Grant
ID number: 1P50CA180890-01
Award Date: 9/19/2013
Institution: University of California San Francisco
The cardiovascular risks of secondhand cigarette smoke, smokeless tobacco (i.e., moist snuff), and e-cigarettes are not adequately understood. This project, a cardiovascular assessment of the effects of tobacco and nicotine, will involve controlled short-term exposures of 88 adult smokers and nonsmokers (aged 21-50) to test products that provide a wide range of nicotine, particle and other cardiovascular toxin concentrations to determine how these components adversely affect cardiovascular risk. Assessment methods will include flow-mediated dilation, heart rate measurement, thromboelastography, Doppler testing, digital vasoconstriction testing, peripheral arterial tonometry, and blood biomarker measurement, and others. Specific aims are: (1) to determine the relative contributions of nicotine and combustion products to the cardiovascular risk associated with active cigarette smoking; (2) to determine which cardiovascular risk biomarkers are affected by exposure to low concentrations of other constituents and secondhand smoke; (3) to determine the cardiovascular risk of smokeless tobacco use; and (4) to determine the cardiovascular risk of electronic cigarettes and the respective contributions of nicotine and electronic cigarette vapor. New biomarkers that can detect differences in the cardiovascular safety of various tobacco products may help inform FDA regulation of conventional, new and emerging products.
Improved Models to Inform Tobacco Product Regulation (TCORS) Related Resources
- Improved Models to Inform Tobacco Product Regulation (TCORS)
- Project 1: The Impact of Changing Tobacco Product Use on Tobacco-Related Disease and Healthcare Costs
- Project 2: The Role of Risk and Benefit Perceptions in Tobacco Control and Product Usage
- Project 3: Smokeless Tobacco Use among Rural High School Males and Resulting Nicotine and Carcinogen Exposure
- Project 4: Quantification and Biomarkers of Short-Term Pulmonary Effects of Tobacco Smoke Exposure: Infection-Related Acute Lung Injury
- The original scientific abstract and other project information can be found on the NIH website
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