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A-TRAC TCORS Project 2: Cardiovascular Injury Due to Tobacco Use

Principal Investigators: Aruni Bhatnagar

Funding Mechanism: National Institutes of Health – TCORS Grant

ID number: 2 U54 HL120163-06

Award Date: 8/31/18

Institution: University of Louisville


The goal of this American Heart Association Tobacco Center for Regulatory Science (A-TRAC) project is to assess and evaluate the cardiovascular effects of non-cigarette tobacco products and to determine whether cardiovascular injury due to tobacco product use is mediated, in part, by exposure to volatile organic chemicals (VOCs) present in or generated by tobacco products. To describe the contribution of VOCs to cardiovascular injury and dysfunction induced by tobacco products, researchers will evaluate the short- and long-term cardiovascular health and disease risk in 555 adult (ages 18-45) users of cigarettes, e-cigarettes, and cigarillos. Study aims are: (1) to identify cardiovascular harm associated with the use of e-cigarettes and cigarillos; (2) to examine the acute cardiovascular effects of e-cigarettes and cigarillos; and (3) to identify cardiovascular disease risk associated with chronic use of e-cigarettes and cigarillos. To accomplish these aims, researchers will examine baseline differences in biomarkers of endothelial injury, inflammation and thrombosis and indices of vascular function and cardiac excitability in e-cigarette and cigarillo users and compare results with cigarette smokers and individuals who do not use tobacco products. To examine long-term effects of tobacco products, researchers will identify progressive changes in cardiovascular disease risk due to continued use of tobacco products over two to six years. Findings will provide new information related to the cardiovascular toxicity of tobacco products and may inform future regulatory activities.


A-TRAC TCORS American Heart Association Tobacco Center for Regulatory Science 2.0: Related Resources