Principal Investigator: Aruni Bhatnagar
Funding Mechanism: National Institutes of Health- TCORS Grant
ID number: 1P50HL120163-01
Award Date: 9/19/2013
Institution: University of Louisville, American Heart Association
Tobacco smoke and tobacco products contain many harmful and potentially harmful constituents (HPHCs) that affect different organ systems and physiological processes. Therefore, an organ-systems approach is the preferred model to understand the adverse health consequences of tobacco use and to reduce tobacco-associated disease. The goal of this project is to understand the cardiovascular effects of tobacco products, with emphasis on early preclinical changes and their subsequent impact on health outcomes. Investigators will determine which cardiovascular disease (CVD) biomarkers are associated with specific measures of tobacco exposure and what magnitude of change in these biomarkers translates into a clinically meaningful impact on CVD outcomes. Specific aims are: (1) to elucidate the relationship between biomarkers of cardiovascular dysfunction/injury and specific measures of exposure to tobacco smoke and smokeless tobacco, by evaluating biomarkers of endothelial damage and predilection for thrombosis in a cross-sectional study of 480 smokers, smokeless tobacco users, and non-smokers without overt CVD (aged 26-45); (2) to identify and compare the dose-dependent associations between tobacco use, measures of subclinical cardiovascular disease, and clinical cardiovascular events, using data from the Multi-Ethnic Study of Atherosclerosis (which includes 6814 participants aged 45-84); and (3) to validate candidate biomarkers associated with tobacco exposure in independent human cohorts, using data from the Jackson Heart Study (which includes 5,301 African American residents of Jackson, Mississippi, aged 35-84). This project will improve the understanding of the cardiovascular consequences of tobacco use, particularly among vulnerable minority populations.