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Toxicant Production and Mitigation in the Electronic-Cigarette Reaction Vessel

Principal Investigator: Robert Strongin

Funding Mechanism: National Institutes of Health - Grant

ID number: 1 R01 ES025257-01

Award Date: 7/7/2015

Institution: Portland State University


E-cigarettes are growing in popularity; however, their health effects are unknown. The goal of this project is to clarify the origins and levels of toxins produced during e-cigarette use as well as the properties of the particles inhaled by users and those exposed to secondhand aerosol. Specific aims are: (1) to define the effect of use on glycerol and propylene glycol, the primary aerosol-forming molecules; (2) to define the effect of use on nicotine and related alkaloids likely to be present in some e-cigarette liquids; (3) to define the effect of flavorings and environmental contaminants on electronic nicotine delivery systems; and (4) to determine the ability of formaldehyde to be released from carrier product molecules and to examine the toxicities of e-cigarette aerosols using various bioassays. Using laboratory analysis techniques such as gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance, researchers will generate predictive models that estimate the products of use and particle size distributions. Study findings may inform regulatory activities related to e-cigarettes.