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  1. Tobacco Science & Research

Stem Cells and Cardiovascular Repair

Stem Cells and Cardiovascular Repair

Principal Investigator: Charles Murry

Funding Mechanism: National Institutes of Health- Grant

ID number: 3P01HL094374-03S1

Award Date: 9/17/2012

Institution: University of Washington

This supplement to an ongoing research project is aimed at determining the effect of smoke exposure on the differentiation of human embryonic stem cells into cardiomyocytes (hESC-CMs) and the effect that smoke exposure has on remodeling of the coronary circulation in mice. Investigators will compare the effect of exposure to smoke generated by traditional cigarettes to that generated by e-cigarettes. Specific aims are: (1) to determine the effect of traditional and e-cigarette smoke on the differentiation and function of hESC-CMs in vitro (e.g., differentiation, migration, proliferation, Ca2+ handling, excitation-contraction [EC] coupling); and (2) to determine the effect of traditional smoke exposure on the remodeling of the coronary circulation in a mouse model of myocardial infarction.