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Smokeless Tobacco Variability Lab Analysis Testing

Principal Investigators: Kenneth Taylor

Funding Mechanism: Research Contract

ID number: HHSF223201310038I

Award Date: 5/1/2018

Institution: Enthalpy Analytical

The goal of this project is to determine the minimal number of testing replicates that provides acceptable variability in the measurement of harmful and potentially harmful constituents (HPHCs) and physical product characteristics data for smokeless tobacco products in the US.  The project has two phases. Phase 1 will measure HPHCs and physical characteristics for a variety of smokeless tobacco products by systematically varying the number of test measurements and will determine the changes in analytical variability to give an optimal number of replicates. Phase 2 will use the optimum number of replicates, determined from Phase 1, and will evaluate inter-batch variability of smokeless tobacco products.  Various products will be tested from common smokeless tobacco subcategories.  Researchers will use published testing methods for benzo[a]pyrene, nicotine, NNN and NNK, pH, and water.  A laboratory-validated method will be used to test acetaldehyde, crotonaldehyde, and formaldehyde levels.  Findings will provide data regarding the number of replicates needed for reliable smokeless tobacco HPHC testing and may inform future regulatory activities. 

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