Rapid Response Characterization of New and Manipulated Tobacco Products (UMD TCORS)

Principal Investigator: Pamela Clark

Funding Mechanism: National Institutes of Health- TCORS Grant

ID number: 1P50CA180523-01

Award Date: 9/18/2013

Institution: University of Maryland College Park

This Center will characterize combustible and non-combustible, conventional, new and manipulated nicotine/tobacco products and the impact of product variations on human behavior and exposure. The Center's projects will measure harm in three contexts: toxicity, consumer acceptance and liking, and bacterial exposure in order to clarify where a product lies in a continuum of harm and provide a scientific basis to inform the regulation of particular product design features. Project 1 will characterize the chemical profiles and physical properties of combustible, noncombustible, conventional, new, emerging, and manipulated tobacco products; using human within-subject crossover acute laboratory trials and an established boost method paradigm, investigators will measure subjects' relative exposures to HPHCs from new and manipulated tobacco products. Through a series of within-subject crossover trials, Project 2 will compare the appeal, consumer acceptance, and likelihood of adoption of combustible tobacco products that differ only on a single characteristic of interest (e.g., menthol concentration, smoke pH). Project 3 will evaluate tobacco microbial constituents and characterize the oral microbiome of tobacco users; investigators will conduct a longitudinal study of tobacco users and nonusers and crossover trials of users who test new and manipulated products.

U.S. Food and Drug Administration

Rapid Response Characterization of New and Manipulated Tobacco Products (UMD TCORS)

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