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Rapid Response Characterization of New and Manipulated Tobacco Products (UMD TCORS)

Principal Investigator: Pamela Clark

Funding Mechanism: National Institutes of Health- TCORS Grant

ID number: 1P50CA180523-01

Award Date: 9/18/2013

Institution: University of Maryland College Park


This Center will characterize combustible and non-combustible, conventional, new and manipulated nicotine/tobacco products and the impact of product variations on human behavior and exposure. The Center's projects will measure harm in three contexts: toxicity, consumer acceptance and liking, and bacterial exposure in order to clarify where a product lies in a continuum of harm and provide a scientific basis to inform the regulation of particular product design features. Project 1 will characterize the chemical profiles and physical properties of combustible, noncombustible, conventional, new, emerging, and manipulated tobacco products; using human within-subject crossover acute laboratory trials and an established boost method paradigm, investigators will measure subjects' relative exposures to HPHCs from new and manipulated tobacco products. Through a series of within-subject crossover trials, Project 2 will compare the appeal, consumer acceptance, and likelihood of adoption of combustible tobacco products that differ only on a single characteristic of interest (e.g., menthol concentration, smoke pH). Project 3 will evaluate tobacco microbial constituents and characterize the oral microbiome of tobacco users; investigators will conduct a longitudinal study of tobacco users and nonusers and crossover trials of users who test new and manipulated products.


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