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Pharmacokinetic Analysis of Nicotine in Sprague-Dawley Rats

Principal Investigator: Susan Chemerynski and Steven Yee

Funding Mechanism:  Internal FDA

ID number: C14049 / E07607.01

Award Date: 11/5/2014

Institution: National Center for Toxicological Research (NCTR)

Accurately predicting nicotine uptake and disposition would be useful for assessing the dose-response effects of nicotine across organ systems. This study will:  (1) establish data on nicotine distribution in rats following exposure through three different routes of administration (intravenous, oral, and inhalation), and (2) generate a mathematical model that determines the parameters of nicotine distribution, metabolism, and excretion in rats.  The results of this study will aid in the understanding of nicotine disposition in blood and other tissues based on the route of administration and will inform model development.