Pennsylvania State University Tobacco Center of Regulatory Science (TCORS)
Principal Investigator: Joshua Muscat and Jonathan Foulds
Funding Mechanism: National Institutes of Health- TCORS Grant
ID number: 1P50DA036107-01
Award Date: 9/30/2013
Institution: Pennsylvania State University
This Center will evaluate the effects of switching smokers from their usual cigarettes to reduced nicotine content cigarettes on nicotine dependence and tobacco harm, with a special focus on vulnerable (e.g. low socioeconomic status [SES], mental disorders) populations. Project 1, a randomized controlled trial, will evaluate the effect of progressive nicotine reduction in cigarettes on smoking behaviors, smoking biomarkers, and stress in smokers with low SES. Project 2, a second randomized controlled trial, will evaluate the effect of progressive nicotine reduction in cigarettes on smoking behavior, toxin exposure, and psychiatric symptoms in smokers with comorbid mood and/or anxiety disorders. Project 3 will evaluate free radical exposure and oxidative stress associated with use of conventional and reduced nicotine cigarettes, via analysis of machine smoking data and a product switch intervention study.
Pennsylvania State University Tobacco Center of Regulatory Science (TCORS) Related Resources
- Project 1: Switching to Progressively Reduced Nicotine Content Cigarettes in Smokers with Lower Socioeconomic Status
- Project 2: Reduced Nicotine Cigarettes in Smokers with Mood and Anxiety Disorders
- Project 3: Free Radical Exposure and Oxidative Stress from Conventional and Reduced Nicotine Cigarettes
- The original scientific abstract and other project information can be found on the NIH website