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Pennsylvania State University Tobacco Center of Regulatory Science (TCORS)

Principal Investigator: Joshua Muscat and Jonathan Foulds

Funding Mechanism: National Institutes of Health- TCORS Grant

ID number: 1P50DA036107-01

Award Date: 9/30/2013

Institution: Pennsylvania State University


This Center will evaluate the effects of switching smokers from their usual cigarettes to reduced nicotine content cigarettes on nicotine dependence and tobacco harm, with a special focus on vulnerable (e.g. low socioeconomic status [SES], mental disorders) populations. Project 1, a randomized controlled trial, will evaluate the effect of progressive nicotine reduction in cigarettes on smoking behaviors, smoking biomarkers, and stress in smokers with low SES. Project 2, a second randomized controlled trial, will evaluate the effect of progressive nicotine reduction in cigarettes on smoking behavior, toxin exposure, and psychiatric symptoms in smokers with comorbid mood and/or anxiety disorders. Project 3 will evaluate free radical exposure and oxidative stress associated with use of conventional and reduced nicotine cigarettes, via analysis of machine smoking data and a product switch intervention study.


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