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OSU TCORS: Understanding Adolescent Trajectories, Exposures and Susceptibilities

OSU TCORS: Understanding Adolescent Trajectories, Exposures and Susceptibilities

Principal Investigator: Peter Shields

Funding Mechanism: National Institutes of Health- TCORS Grant

ID number: 1P50CA180908-01

Award Date: 9/19/2013

Institution: Ohio State University


Most smokers and smokeless tobacco (ST) users initiate use prior to the age of 18. ST use among adolescents has been increasing and the prevalence of dual use of ST and cigarettes is especially high in Ohio. However, almost nothing is known about adolescent initiation of ST and dual use, trajectories to regular use and dependence, exposures through biomarkers, and environmental and genetic risk factors. Investigators will survey 1050 rural and 1050 urban Ohio males aged 11-14 and analyze oral rinses and urine samples to evaluate trajectories from experimentation to regular use and dependence, degree of nicotine exposure with biochemical confirmation, and level of nicotine dependence; investigators will also measure carcinogen exposures and consider various genetic risk factors. Specific aims are: 1) to determine the time from experimentation to regular use of and dependence on various tobacco products (including cigarettes, chew, snuff, snus, and dissolvables), based on product nicotine levels and adjusted for environmental predictors of initiation (e.g., family and peer tobacco use, advertising and media); 2) to determine the differences in tobacco toxicant exposure among daily or near-daily ST users, smokers, and dual users using conventional and novel biomarkers of exposure (e.g., metabolomics); and 3) to identify genetic susceptibilities that influence ST use, smoking and dual use (i.e., nicotine metabolic ratio and genes associated with nicotine metabolism, neurobehavior and taste perception), using mouthwash samples from 2570 adolescents and 4626 parents.  This project will provide new information about tobacco use trajectories among youth with regard to ST and dual use.


OSU Center of Excellence in Regulatory Tobacco Science (OSU-CERTS) (TCORS) Related Resources