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Nicotine Delivery from Novel Non-Tobacco Electronic Systems

Nicotine Delivery from Novel Non-Tobacco Electronic Systems

Principal Investigator: Maciej Lukasz Goniewicz

Funding Mechanism: National Institutes of Health- Grant

ID Number: 1R01DA037446-01

Award Date: 8/26/2014

Institution: Roswell Park Cancer Institute Corporation 


Electronic nicotine delivery devices (ENDS) are novel products that electronically generate a nicotine-containing vapor that is inhaled by the user. Electronic cigarettes (e-cigarettes) are the most popular ENDS on the market, but various types and brands exist and are engineered differently, and thus vary in their nicotine delivery to the user. The goal of this project is to evaluate various e-cigarettes and to establish an evidence base for evaluating their potential for nicotine delivery. Specific aims are: (1) to measure the amounts of nicotine present in various brands and types of e-cigarettes as well as the nicotine yields in vapors generated by the devices; (2) to investigate the levels of nicotine delivered by e-cigarettes to the bloodstream compared to levels delivered by conventional cigarettes (in a group of 18 adult smokers aged 18 and older), and the effect of e-cigarette nicotine solution flavorings on puff topography and nicotine delivery (in a second group of 18 adult smokers aged 18 and older); and (3) to develop a machine smoking protocol for various types of e-cigarettes that reflect users’ puffing behavior and product characteristics. These findings may inform the development and implementation of e-cigarette quality standards and testing methods.


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