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Method Development for Biomarkers of Priority HPHCs

Principal Investigator: Maocheng (Tony) Yang

Funding Mechanism: Interagency Agreement

ID number: 224-10-9022

Award Date: 1/1/2011

Institution: Centers for Disease Control and Prevention


An understanding of the levels of harmful and potentially harmful constituents (HPHCs) in tobacco smoke and smokeless tobacco products will inform FDA regulatory activities. This project involves further development of analytical procedures to measure HPHC levels in smoke and smokeless tobacco products and, when possible, development into high-throughput methods. The contracted laboratory will work to develop high quality methods for all select HPHCs identified by the Center for Tobacco Products (CTP) in smoke and smokeless tobacco products. When technically feasible, the laboratory will incorporate these constituents into existing analysis methods or develop new methods that encompass multiple constituents of a similar nature. Once developed and validated, these test methods may be used to measure HPHC levels in tobacco products.

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