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Improved Models to Inform Tobacco Product Regulation (UCSF TCORS)

Principal Investigator: Stanton Glantz

Funding Mechanism: National Institutes of Health - TCORS Grant

ID number: 1P50CA180890-01

Award Date: 9/19/2013

Institution: University of California, San Francisco

This Center will study (1) the economic impacts of tobacco use on health costs; (2) risk perceptions, perceived acceptability, consumer responses to pro-tobacco marketing and anti-tobacco messages and other behavioral and social determinants of tobacco use; and (3) rapid changes in risk due to tobacco use and secondhand smoke exposure as manifested in cardiovascular and pulmonary dysfunction, allowing the identification of functional biomarkers of acute cardiopulmonary responses to tobacco use. Project 1 will develop microeconomic models to characterize the impact of changing tobacco product use on tobacco-related disease and healthcare costs. Project 2 will use a longitudinal cohort design to study the role of adolescents’ and young adults’ risk and benefit perceptions related to tobacco use, marketing, and control. Project 3 will study smokeless tobacco use among rural high school males. Project 4 will quantify, and identify biomarkers of, the short-term pulmonary effects of smoking and secondhand smoke exposure. Project 5, a cardiovascular assessment of the effects of tobacco and nicotine, will involve controlled short-term exposures of human subjects to test products that provide a wide range of nicotine, particle and other cardiovascular toxin concentrations to determine how these components adversely affect cardiovascular risk.

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