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HPHC Level Monitoring of Tobacco Products

Principal Investigator: Clifford Watson and Matthew Walters

Funding Mechanism: Interagency Agreement

ID number: 224-10-9022

Award Date: 10/1/2016

Institution: Centers for Disease Control and Prevention (CDC)


The identities and quantities of harmful and potentially harmful constituents (HPHCs) in different tobacco products, including newly deemed tobacco products commercially available in 2016-2017, is critical information that can be used to protect the public health. This study involves analyzing 30 brands of each type of tobacco product (e.g., cigarettes, smokeless tobacco, roll-your-own tobacco, pipe tobacco, waterpipe tobacco, e-cigarettes) representing the top, middle, middle-low, and low quartiles of market share for each tobacco type in and around the Atlanta metropolitan area.  Researchers will analyze 33 HPHCs using various methods, including high performance liquid chromatography-mass spectrometry (HPLC-MS).  Data on moisture, pH, tar, and engineering parameters will also be collected on the different tobacco products.  The project is expected to be performed in three six-month phases.  Phase 1 will include testing cigarette filler, roll-your-own tobacco filler, pipe tobacco, waterpipe tobacco and smokeless tobacco.  Phase 2 will include testing cigarette smoke under intense and non-intense smoking regimens.  Phase 3 will include testing e-cigarette liquids and aerosols.  Study findings will provide a better understanding of the constituent yields for 33 HPHCs across tobacco product types and may inform regulatory activities related to HPHCs.