Principal Investigators: Carol Swartz and Mamata De
Funding Mechanism: Research Contract
ID number: HHSF223201510009I
Award Date: 9/11/2017
Institution: Integrated Laboratory System
More information about the potential of flavoring ingredients to cause genotoxicity (gene toxicity) would be useful. The primary objective of this study is to conduct a high throughput mammalian cell genotoxicity study using commercially-available validated genotoxicity screening assays. The results from the screening assays will indicate whether a flavor ingredient is potentially genotoxic and, for those that are positive, describe the mechanism of action of the genotoxic effects. The secondary objective is to conduct statistical quantitative structure-activity relationship (QSAR) and structure-activity relationship (SAR) analyses for predicting the genotoxicity of the flavoring agents tested in the screening assay. Comparing the results of the QSAR and SAR analyses with the findings of the in vitro screening assays will help in the creation of a predictive model for genotoxicity assessment of the flavoring ingredients in tobacco products.