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Exploratory Study on the Effect the Format of Moist Smokeless Tobacco (Loose vs. Portioned) has on the Use Behaviors, Nicotine Exposure and Tobacco Dependence in Current Users

Exploratory Study on the Effect the Format of Moist Smokeless Tobacco (Loose vs. Portioned) has on the Use Behaviors, Nicotine Exposure and Tobacco Dependence in Current Users

Principal Investigator: Wallace Pickworth and Lynn Hull

Funding Mechanism:  Research Contract

ID number: HHSF223201310030I; HHSF22301002T

Award Date: 7/3/2014

Institution: Battelle Health and Analytics


Use patterns may be different for portioned and loose (non-portioned) smokeless tobacco (ST) products; depending upon type of product used, users may alter their use behavior along measures such as frequency of use (e.g., mean use per day, total use per day), deposition time in the mouth, and amount of product used per occasion. Such changes in use behavior may affect nicotine exposure. However, little is known about the relationship between type of product, use behavior, and resulting nicotine exposure. The primary aim of this study is to investigate the behavioral aspects of ST use among users of loose and portioned moist ST products.  Endpoints of interest include amount used, deposition time in the mouth, and frequency of use. This study will also characterize differences in nicotine exposure from normal use of loose or portioned ST products and investigate the potential for nicotine dependence among adult moist ST product users (ages 18-65). Investigators will enroll 30 adult users of portioned ST and 30 adult users of loose ST for a one-day study session to evaluate the way they use the ST product and the resulting nicotine exposure. In addition, subjects will be administered a number of questionnaires to evaluate their ST dependence.  This study will provide new information about comparative ST use patterns and nicotine exposure that may be used to inform regulatory activities.