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Expanded Samples Analysis of NHANES Self-Reporting Smokers Project

Principal Investigator: Ben Blount

Funding Mechanism: Interagency Agreement

ID number: 224-10-9022

Award Date: 10/1/2011

Institution: Centers for Disease Control and Prevention

The National Health and Nutrition Examination Survey (NHANES) – conducted by the Centers for Disease Control and Prevention (CDC) National Center for Health Statistics (NCHS) -- is a national survey of non-institutionalized youth and adult civilians in the United States. NHANES includes a representative sample of approximately 10,000 participants in each two-year survey cycle and combines interviews and physical examinations to identify the prevalence of major diseases and disease risk factors. Information collected includes detailed cigarette smoking information as well as data on recent use of other tobacco/nicotine-containing products including pipes, cigars, smokeless tobacco, snuff, and nicotine replacement therapy. As part of NHANES, the CDC Division of Laboratory Sciences analyzes participant urine samples in order to measure biomarkers of different analytes, some of which have been shown to be markers of harmful and potentially harmful constituents (HPHCs) in tobacco smoke. The goal of this project, an enrichment of the 2011-2012 NHANES wave, is to expand the urine biomarker analysis to include approximately 960 self-reported smokers age 20 or older. DLS will analyze urine samples for four classes of tobacco exposure biomarkers: polycyclic aromatic hydrocarbons (PAHs), metals, volatile organic compound (VOC) metabolites, and thiocyanate. The expanded measurement of tobacco exposure biomarkers will enhance epidemiological and health sciences research studies that use NHANES data; furthermore, this project has the potential to inform FDA’s regulatory activities related to setting product standards and conducting application review.

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