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  1. Tobacco Science & Research

Evaluation of Tobacco Use and Cardiovascular Diseases

Evaluation of Tobacco Use and Cardiovascular Diseases

Principal Investigator: Jiping Chen

Funding Mechanism: Research Contract

ID number: HHSF223201210415A

Award Date: 9/19/2012

Institution: American College of Cardiology


The goal of this project is to examine tobacco use patterns in a representative nationwide sample of patients with mild cardiovascular diseases using an existing database, and evaluate the associations between the use of various tobacco products and health outcomes. The project will use data collected in the PINNACLE Registry, which is the largest practice-based cardiovascular registry in the United States and includes more than six million patient encounter records. Investigators will analyze records from 1,318,235 patients treated at 114 medical practices from January 2008 to March 2013. Tobacco use patterns (e.g., prevalence of current use, recent use, and poly use by calendar year, and recent cessation patterns), cardiac event history, new comorbidities, new cardiovascular events, and progression of coronary heart disease associated with tobacco use will be analyzed. Study aims are: (1) to describe the patterns of use of various tobacco products (i.e., cigarettes, cigars, pipes, smokeless tobacco) and changes in use over time among individuals with mild cardiovascular diseases; and (2) to analyze the associations between current and former tobacco use and various cardiovascular health outcomes. Study findings may help inform FDA regulatory activities.