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Establishing Matrix-Specific Harmful and Potentially Harmful Constituents Lists (Phase 3, Task Order 2)

Principal Investigators: Karen Carter and Shixia Feng

Funding Mechanism: Research Contract

ID number:  HHSF22301003T

Award Date: 5/12/2017

Institution: Enthalpy Analytical, Inc.


More information about which harmful and potentially harmful constituents (HPHCs) are present in specific types of tobacco samples – particularly the newly deemed tobacco products -- would be useful. The primary goal of this study is to establish product/sample type-specific HPHC lists through laboratory testing. A second goal is to establish baseline values for the HPHCs present in each product/sample type. Products will be selected for testing based on market volumes, product features, and types/subcategories. Because of its broad scope, this study includes three phases, with one or two task orders under each phase. In Phase 3-Task Order 2, testing will focus on hookah tobacco and smokeless tobacco products. HPHCs to be investigated will include amide, caffeic acid, coumarin, ethyl carbamate, hydrogen cyanide, non-tobacco specific nitrosamines, polycyclic aromatic hydrocarbons, and volatiles. Study findings may inform regulatory activities related to product testing, reporting, and evaluation.