U.S. flag An official website of the United States government
  1. Home
  2. Tobacco Products
  3. Tobacco Science & Research
  4. Research
  5. Establishing Matrix-Specific Harmful and Potentially Harmful Constituents Lists (Phase 2, Task Order 2)
  1. Research

Establishing Matrix-Specific Harmful and Potentially Harmful Constituents Lists (Phase 2, Task Order 2)

Principal Investigators: Karen Carter and Shixia Feng

Funding Mechanism: Research Contract

ID number: HHSF22301004T

Award Date: 5/17/2017

Institution: Enthalpy Analytical, Inc.


More information about which harmful and potentially harmful constituents (HPHCs) are present in specific types of tobacco samples – particularly the newly deemed tobacco products -- would be useful. The primary goal of this study is to establish product/sample type-specific HPHC lists through laboratory testing. A second goal is to establish baseline values for the HPHCs present in each product/sample type. Products will be selected for testing based on market volumes, product features, and types/subcategories. Because of its broad scope, this study includes three phases, with one or two task orders under each phase. In Phase 2-Task Order 2, testing will focus on pipe tobacco, cigar tobacco, and cigar smoke. HPHCs to be investigated will include coumarin, hydrogen cyanide, PAHs, non-tobacco specific nitrosamines, caffeic acid, ethyl carbamate, and tobacco specific alkaloids. Study findings may inform regulatory activities related to product testing, reporting, and evaluation.