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Establishing Matrix-Specific Harmful and Potentially Harmful Constituents Lists (Phase 2, Task Order 1)

Principal Investigators: Andrew Mooney and Shixia Feng

Funding Mechanism: Research Contract  

ID number: HHSF22301008T

Award Date: 5/31/2017

Institution: Labstat International ULC


More information about which harmful and potentially harmful constituents (HPHCs) are present in specific types of tobacco samples – particularly the newly deemed tobacco products -- would be useful. The primary goal of this study is to establish product/sample type-specific HPHC lists through laboratory testing. A second goal is to establish baseline values for the HPHCs present in each product/sample type. Products will be selected for testing based on market volumes, product features, and types/subcategories. Because of its broad scope, this study includes three phases, with one or two task orders under each phase. In Phase 2-Task Order 1, testing will focus on roll-your-own tobacco, pipe tobacco, cigar tobacco, and cigar smoke. HPHCs to be investigated will include aflatoxin, amide, metals, non-tobacco specific nitrosamines, PAHs, phenols, tobacco specific alkaloids, dioxins, heterocyclic aromatic amines, and hydrazine. Study findings may inform regulatory activities related to product testing, reporting, and evaluation.

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