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Establishing Matrix-Specific Harmful and Potentially Harmful Constituents Lists (Phase 1, Task Order 2)

Establishing Matrix-Specific Harmful and Potentially Harmful Constituents Lists (Phase 1, Task Order 2)

Principal Investigators: Karen Carter and Shixia Feng

Funding Mechanism:  Research Contract

ID number:  HHSF22301002T

Award Date: 3/17/2017

Institution:  Enthalpy Analytical, Inc.


More information about which harmful and potentially harmful constituents (HPHCs) are present in specific types of tobacco samples – particularly the newly deemed tobacco products -- would be useful. The primary goal of this study is to establish product/sample type-specific HPHC lists through laboratory testing. A second goal is to establish baseline values for the HPHCs present in each product/sample type. Products will be selected for testing based on market volumes, product features, and types/subcategories. Because of its broad scope, this study includes three phases, with one or two task orders under each phase. In Phase 1-Task Order 2, testing will focus on cigarette smoke, cigar smoke, and smokeless tobacco products. HPHCs to be investigated will include aflatoxin, coumarin, non-tobacco specific nitrosamines, volatiles, heterocyclic aromatic amines, and hydrogen cyanides. Study findings may inform regulatory activities related to product testing, reporting, and evaluation.