Principal Investigator: N. Rajendran and Alex Tu
Funding Mechanism: Research Contract
ID number: HHSF223201510000I
Award Date: 3/2/2016
Institution: Illinois Institute of Technology (IIT) Research Institute
Acrolein, one of the most toxic aldehydes in cigarette smoke, is a respiratory irritant that contributes to the inflammation and lung disease caused by cigarette smoke. While menthol reduces the irritation response to acrolein, how menthol influences the effects of cigarette smoke and acrolein on lung inflammation is currently unknown. The goal of this in vitro cell-based study is to determine how menthol influences the effects of acrolein on lung inflammation. Study aims are: (1) to characterize and identify dose ranges of acrolein and cigarette smoke on inflammation markers in lung epithelial cells, and (2) to understand the effects of menthol on acrolein- and smoke-induced lung inflammation in lung epithelial cells. Findings will contribute new information regarding the dose ranges and mechanisms of acrolein and cigarette smoke actions related to inflammation and cell death.