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The Effect of Menthol on ENDS Users' Dependence, Respiratory, and Toxicants Emission Outcomes

Principal Investigator: Wasim Maziak
Funding Mechanism: National Institutes of Health - Grant
ID Number: 1R01DA055937-01
Award Date: 3/22/2022
Institution: Florida International University


The goal of this study is to clarify how menthol affects electronic nicotine delivery system (ENDS) users' experience and puffing patterns, which in turn affect dependence, exposure to toxicants, and clinical outcomes. In this study, 200 current/past month closed-system ENDS users (ages 21-35) will attend two laboratory sessions and use their ENDS once with menthol flavor and once with tobacco flavor. Study aims are: (1) to test the effects of menthol vs. tobacco flavor on subjective, puffing, and respiratory outcomes including pre-post-use assessment of craving, withdrawal, satisfaction, harm perception, intention to quit or use, respiratory functions, and symptoms (e.g., dry mouth, irritation, cough, palpitation, nausea); and (2) to use a smoking robot to measure the effects of menthol vs. tobacco flavor on ENDS emissions of 14 aldehydes. Findings may inform future regulatory activities related to the use of menthol flavor in ENDS. 

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