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E-Cigarettes: Dynamic Patterns of Use and Health Effects

Principal Investigator: Megan Piper and Douglas E. Jorenby

Funding Mechanism:  National Institutes of Health - Grant

ID number: 1 R01 CA190025-01

Award Date: 2/3/2015

Institution: University of Wisconsin-Madison

E-cigarettes have been rapidly adopted in the U.S., but data on e-cigarette use and its effects are limited. This study will generate in-depth, long-term data based on real-time reports that will examine the relationship between e-cigarette use and: 1) nicotine dependence; 2) reductions in conventional cigarette use; 3) health-related indicators such as biomarkers of exposure, carcinogens, and acute and long-term pulmonary health; and 4) attempts to quit conventional cigarette use and the success of those attempts. Over two years, investigators will collect data from 150 adult smokers (ages 18 and older) who exclusively smoke conventional cigarettes and 250 adult dual users of e-cigarettes (ages 18 and older) and conventional cigarettes. Investigators will use ecological momentary assessment to determine: 1) changing patterns of e-cigarette and conventional cigarette use and related outcomes (e.g., dependence, withdrawal symptoms, reward value, conventional cigarette quit attempts and quitting success); 2) stable and episodic variables (e.g., lifestyle factors, demographics) that vary with e-cigarette and conventional cigarette use and related outcomes; and 3) targeted biomarkers of tobacco and carcinogen exposure as well as other health-related outcomes (e.g., pulmonary function). Investigators will analyze data gathered over time and will compare the dual use and conventional cigarette use groups. This study will yield information about patterns of real-world e-cigarette use and how such use is related to conventional cigarette smoking and associated health risks, and may inform future regulatory activities.

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