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Dissolution of Smokeless Tobacco Products

Principal Investigators: Mimy Young 

Funding Mechanism: Research Contract

ID number: HHSF223201810173P

Award Date: 8/17/2018

Institution: Texas A&M

The purpose of this study is to characterize the nicotine release profiles of smokeless tobacco products available in the US to investigate the effects of tobacco blend changes, formulation changes, pH changes, and differences in physical parameters on nicotine release and to create a baseline for product comparison. Study aims are: (1) to develop and validate a method for nicotine quantification using high performance liquid chromatography/ultra-performance liquid chromatography-mass spectrometry (HPLC/UPLC-MS) to measure nicotine in the selected dissolution medium; and (2) to develop and validate dissolution methods (USP 4 and Chewing gum tester) for different categories of smokeless tobacco products and to analyze their nicotine release profiles. Findings will provide new information about the effects that different tobacco blends, pouch materials, pH buffers and buffering capacity, and other additives have on nicotine release from smokeless products. 

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