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Differential Redox & Electrophilic Toxicities of Modified Tobacco Products

Principal Investigator: Norbert Staimer

Funding Mechanism: National Institutes of Health- Grant

ID number: 1R21CA164540-01A1

Award Date: 4/1/2013

Institution: University of California Irvine

Cigarette smoke is a toxic mixture of approximately 4,700 chemical compounds that can cause irreversible oxidative stress-induced damage to lung epithelial cells, resulting in cardiovascular disorders, chronic obstructive pulmonary disease, and lung cancer. However, comparative emission data for combustible potential “modified risk” tobacco products are rare, and a comprehensive toxicity assessment outside of the tobacco industry is lacking. The goal of this project is to characterize the toxic effects of electrophilic and/or redox-active conjugated ketones from 10-15different brands of cigarettes, including reference cigarettes, cigarettes with a wide range of tar and nicotine content, no-filter and charcoal filter cigarettes, a low combustion potential modified risk tobacco product, and electronic cigarettes. Specific aims are: (1) to develop methods to generate, sample and quantify electrophilic gas-phase carbonyls and tar-phase quinones in cigarette smoke; (2) to assess the electrophilic and redox potential of gas phase carbonyls and tar phase quinones in cigarette smoke extracts derived from different types of cigarettes; and (3) to assess the differential effects of modified tobacco product smoke components on the antioxidant defense mechanisms of cultivated primary small airway epithelial cells.

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