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Development of Physiological Models and Software Tools for Health Risk Evaluation of e-Cigarettes

Principal Investigators: Jeffry Schroeter and Susan Chemerynski

Funding Mechanism: Research Contract

ID number: HHSF223201610113C

Award Date: 9/21/2016

Institution: Applied Research Associates, Inc


More information about the potential oral and respiratory health impacts of electronic nicotine delivery systems (ENDS) use would be useful for potentially informing future regulatory activities. Investigators will develop comprehensive physiological models of the oral airway and respiratory tract that can be used to assess how ENDS aerosol constituents (e.g., nicotine, humectants, flavorings, byproducts) are deposited and absorbed. The models will assess the deposition and distribution of these constituents using computational fluid dynamics, multiple path particle and aerosol dosimetry, and pharmacokinetic data. These models will then be integrated into a software platform that will incorporate toxicological data and physiological modeling results to enable the evaluation of ENDS constituents’ health risks. This project will help support the evaluation of ENDS aerosol dosimetry, potential toxicity, and health risks.