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CTP Supplement to Parent Grant: Reactions to Reduced Nicotine Cigarettes in Young Adult Low- Frequency Smokers-Supplement

Principal Investigator(s): Francis Joseph McClernon

Funding Mechanism: NIH Grant

ID number: 3R01DA042532-03S1

Award Date: 8/6/2018

Institution: Duke University


The goal of the parent study was to evaluate reactions to and choices of cigarettes with varying nicotine content among low-frequency, non-dependent smokers aged 18-25 years; this supplement extends the age range of the sample by recruiting and collecting data from adolescents aged 15-17 years. (Note: The research plan was developed in consultation with an expert in adolescent smoking research; all participants will be given information about smoking cessation resources.) As in the parent study, participants will undergo three sessions in which they will receive fixed doses of smoke from investigational cigarettes with three different nicotine content levels (15.8 mg/g, 2.5 mg/g, and 0.4 mg/g of tobacco). Following the third fixed-dose session, participants will return to the lab to choose one of the cigarettes to self-administer. Study aims are: (1) to combine the 15-17-year old sample with the parent grant sample and evaluates initial reactions to, and choices of, cigarettes with varying nicotine content; and (2) to identify correlates of reactions to, and choices of, cigarettes with varying nicotine content in the entire sample of low-frequency smokers. Findings will present an evaluation of the amount of nicotine in cigarette smoke that produces reactions associated with progression from initial smoking to nicotine dependence in a sample representative of individuals experimenting with cigarette use.