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CTP Supplement to Parent Grant: Metals in Electronic Cigarette Aerosol

CTP Supplement to Parent Grant: Metals in Electronic Cigarette Aerosol

Principal Investigators: Prudence Talbot

Funding Mechanism:  National Institutes of Health - Grant

ID number:  3R01DA036493-04S1

Award Date: 8/15/2017

Institution: University of California, Riverside

This study is a supplement to a parent study that sought to identify and quantify the metal content of e-cigarette aerosols from various products and designs, to examine the cell and gene toxicity of aerosols with metal content, and to examine biomarkers of metal exposure and health effects in e-cigarette users. E-liquids often contain high concentrations of the flavor chemicals menthol (M-ol) and/or menthone (M-one) and cinnamaldehyde (CAD). This supplemental project will: (1) identify and quantify flavor chemical degradation products formed by vaping e-liquids containing M-ol, M-one, and CAD; and (2) determine which in vitro assays best assess the toxicity of e-cigarette aerosols and which reaction products cause toxicity. This study will provide new information about e-cigarette aerosol toxicity.