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CTP Supplement to Parent Grant: Interactions between Tobacco Smoke Constituents in Rodent Tumor Models

Principal Investigators: Lisa Peterson

Funding Mechanism: National Institutes of Health - Grant

ID number: 3R01CA184987-04S1

Award Date: 7/3/2017

Institution: University of Minnesota

This study is a supplement to a parent project that sought to characterize the potential interactions between known human carcinogens (e.g., NNK, NNN, BaP) and volatile components of tobacco smoke (e.g., acetaldehyde, acrolein, formaldehyde) in established rodent tumor models. This study will add a histopathological analysis (an analysis of tissue changes) to the previous study analyses; histopathological analysis will provide additional useful information for the detection of the interaction between acetaldehyde or formaldehyde (two tobacco-associated lung carcinogens) and NNK. Taken together, these analyses will provide important information about the ability of volatile compounds to influence the tumor-generating activity of established tobacco carcinogens.