Principal Investigators: Lisa Peterson
Funding Mechanism: National Institutes of Health - Grant
ID number: 3R01CA184987-04S1
Award Date: 7/3/2017
Institution: University of Minnesota
This study is a supplement to a parent project that sought to characterize the potential interactions between known human carcinogens (e.g., NNK, NNN, BaP) and volatile components of tobacco smoke (e.g., acetaldehyde, acrolein, formaldehyde) in established rodent tumor models. This study will add a histopathological analysis (an analysis of tissue changes) to the previous study analyses; histopathological analysis will provide additional useful information for the detection of the interaction between acetaldehyde or formaldehyde (two tobacco-associated lung carcinogens) and NNK. Taken together, these analyses will provide important information about the ability of volatile compounds to influence the tumor-generating activity of established tobacco carcinogens.