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CTP Supplement to Parent Grant: Evaluating Concomitant Use of Very Low Nicotine Content Cigarettes and E-cigarettes Among Daily and Non-Daily Smokers on Abuse Liability

Principal Investigators: Paul Cinciripini

Funding Mechanism:  National Institutes of Health - Grant

ID number:  3R01DA042526-02S1

Award Date: 5/31/2017

Institution:  University of Texas MD Anderson Cancer Center


This study is a supplement to a parent study that modeled abuse liability in a market in which the combustible cigarette nicotine level was lowered to meet a potential regulatory standard, but an alternate source of nicotine in the form of e-cigarettes was also available. The coexistence of these products raises questions about whether the potential public health benefit of reducing abuse liability with low nicotine cigarettes might be offset by the concurrent use of e-cigarettes. In this supplemental study, researchers will quantify the formaldehyde DNA adduct N6-hydroxymethyldeoxyadenosine in leukocyte DNA samples collected via cheek swabs of 160 adult e-cigarette users aged 18-65. This will provide a measure of exposure to a potential toxicant specific to e-cigarettes, and will complement the biomarkers of combustible tobacco and nicotine exposure included as part of the parent study.