Principal Investigators: Paul Cinciripini
Funding Mechanism: National Institutes of Health - Grant
ID number: 3R01DA042526-02S1
Award Date: 5/31/2017
Institution: University of Texas MD Anderson Cancer Center
This study is a supplement to a parent study that modeled abuse liability in a market in which the combustible cigarette nicotine level was lowered to meet a potential regulatory standard, but an alternate source of nicotine in the form of e-cigarettes was also available. The coexistence of these products raises questions about whether the potential public health benefit of reducing abuse liability with low nicotine cigarettes might be offset by the concurrent use of e-cigarettes. In this supplemental study, researchers will quantify the formaldehyde DNA adduct N6-hydroxymethyldeoxyadenosine in leukocyte DNA samples collected via cheek swabs of 160 adult e-cigarette users aged 18-65. This will provide a measure of exposure to a potential toxicant specific to e-cigarettes, and will complement the biomarkers of combustible tobacco and nicotine exposure included as part of the parent study.