Principal Investigator: Daniel Langleben
Funding Mechanism: National Institutes of Health- Grant
ID number: 1R01DA036028-01
Award Date: 7/1/2013
Institution: University of Pennsylvania
Additional scientific evidence regarding the impact of graphic warning labels (GWLs) will inform mechanisms underlying the effectiveness of strongly salient format and content in persuasive health communications. This project addresses this issue from both a clinical and neurophysiological perspective; investigators will use biochemical assays (urine cotinine levels) and neuroimaging (functional magnetic resonance imaging [fMRI]), as well as traditional measures of persuasion, to compare brain and bio-behavioral responses to GWLs that were rated high or low on the emotional response (ER) scale. Investigators will image the brain response to GWLs and monitor urine cotinine levels before and after four-week exposure to real-life cigarette packs carrying high or low ER GWLs in adult smokers who are not seeking smoking cessation treatment. Specific aims are: (1) to compare the effects of exposure to high or low ER GWLs on urine cotinine levels, a quantitative measure of smoking behavior/severity, and (2) to characterize the longitudinal effects of exposure to high or low ER GWLs on fMRI response in the key brain regions that are involved in processing and responding to affective stimuli. By evaluating the effects of the long-term exposure to GWLs of different affective levels on the brain and behavioral correlates of smoking behaviors, this study can inform science-driven regulation of cigarette packaging.