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Behavior and Toxicant Exposure among Dual Users of Cigarettes and E-Cigarettes

Behavior and Toxicant Exposure among Dual Users of Cigarettes and E-Cigarettes

Principal Investigator: Caroline O. Cobb

Funding Mechanism: National Institutes of Health- Grant

ID Number: 1R21CA184634-01

Award Date: 9/16/2014

Institution: Virginia Commonwealth University


Little is known about how dual use of traditional cigarettes and electronic cigarettes (e-cigarettes) influences measures of tobacco-related harm, including use patterns and toxicant exposure. The goal of this study is to evaluate measures of potential harm associated with dual cigarette and e-cigarette use. Specific aims are: (1) to evaluate changes in tobacco product consumption during dual use in comparison to single product use; and (2) to evaluate changes in toxicant exposure during dual use in comparison to single product use and no tobacco/nicotine use. Researchers will enroll 28 dual users of cigarettes and e-cigarettes aged 18-60 to complete four study conditions (dual use, cigarette-only use, e-cigarette-only use, and no tobacco/nicotine use), each lasting five days. Researchers will evaluate and compare conditions by measuring product consumption, toxicant exposure (i.e., carbon monoxide, cotinine, and total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol [NNAL]), physiological data (i.e., heart rate, blood pressure), and subjective indicators related to nicotine effects and nicotine abstinence-related symptoms. Results may provide new information about whether dual use of cigarettes and e-cigarettes decreases, has little effect on, or increases measures of potential harm relative to single product use and no tobacco/nicotine use.


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