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Assessment of Tobacco Product Pharmacology and Behavior in Humans: Behavioral Pharmacology Associated with Cigar Smoking

Principal Investigator: Darlene Harbour and Megan Schroeder

Funding Mechanism: Research Contract

ID number: HHSF223201310033I

Award Date: 9/26/2013

Institution: Lovelace


Although many studies have investigated the effects of cigarette smoking on human behavior and biomarkers of exposure, our knowledge of how cigar smoking affects human behavior and pharmacology remains limited. The goal of this project is to better understand the dependence behaviors and biomarkers of exposure associated with cigar use. In 66 adult cigar-only smokers, the investigators will conduct a clinical study measuring dependence (both real and perceived), withdrawal relief, and craving using existing and modified behavioral scales and assessments. In addition, investigators will gather data on participants’ smoking topography (including latency to first puff, puff number, interpuff interval, and smoking duration) associated with smoking their usual type and brand of cigar, self-reported inhalation behaviors, and exhaled carbon monoxide. Investigators will also collect urine and blood samples to measure biomarkers of exposure (including nicotine, cotinine, and total NNAL).  The study will compare the dependence behaviors and pharmacology associated with the use of small versus large cigars, as well as biomarkers of exposure in cigar smokers who are and are not former cigarette smokers. This study will yield information on dependence behaviors and biomarkers of exposure associated with cigar smoking and may provide critical information on the impact of these tobacco products on the public health.

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