AMPK as a Redox Sensor and Modulator
Principal Investigator: Ming-Hui Zou
Funding Mechanism: National Institutes of Health- Grant
ID number: 2R01HL089920-05
Award Date: 9/12/2012
Institution: University of Oklahoma Health Sciences Center
Abdominal aortic aneurysm (AAA) is the most common form of aortic aneurysm and uncontrolled growth of AAAs frequently leads to rupture resulting in approximately 80% mortality. Epidemiological studies suggest that cigarette smoke increases the risk of AAAs 7.6-fold and smoking is the only modifiable factor associated with the development, expansion, and rupture of AAAs. In this study, a combination of pharmacological, molecular, and genetic methodologies will be used to explore the link between cigarette smoke and AAAs in animals in vivo. The completion of this project will increase our understanding of aneurismal degeneration associated with smoking and may inform cardiovascular models of toxicity associated with tobacco exposure.