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Adolescent ENDS Use, Nicotine Metabolism and Toxicant Exposure

Principal Investigator: Mark Rubinstein

Funding Mechanism: National Institutes of Health – Grant

ID number: 1R21DA040718-01

Award Date: 8/15/2016

Institution: University of California, San Francisco


Use of electronic nicotine delivery systems (ENDS), such as e-cigarettes, is increasing among adolescents. The goal of this study is to investigate e-cigarette toxicant levels and the influence of nicotine metabolism rate on use behaviors and nicotine dependence in adolescents. Study aims are: (1) to investigate the level of toxicants including propylene oxide, acrolein, ethylene oxide, benzene, acrylamide, formaldehyde, and 1,3, butadiene found in adolescent ENDS-only users; and (2) to examine the association between nicotine metabolism rate (measured by the salivary 3’hydroxycotinine/cotinine ratio) and the frequency of ENDS use and reported dependence in adolescent ENDS-only users. Researchers will enroll 180 adolescent ENDS-only users (aged 13-17 years) and a control group of 20 similarly-aged non-smokers/non-ENDS users. Researchers will analyze urine to determine toxicant levels and saliva to determine the nicotine metabolism rate. ENDS behavior questionnaires and nicotine dependence scales will be administered.

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