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Dockets Management


RPT 266
Volumes 195-197

Cover Page, Correspondence, and New Dietary Ingredient Notification for Kaneka QH


Aberg, F.; Appelkvist, E.L.; Dallner, G,; Ernster, L. 1992. Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys 295: 230-234. Cited In: Podda et al., 1996. Published Material

Arroyo, A.; Kagan, V.E.; Tyurin, V.A.; Burgess, J.R.; de Cabo, R.; Navas, P. 2000. NADH and NADPH-dependent reduction of coenzyme Q at the plasma membrane. Antioxidants & Redox Signaling 2 (2): 251-262. Published Material

Baggio, E.; Gandini, R.; Plancher, A.C.; Passeri, M.; Carmosino, G. 1994. Italian mulitcenter study on the safety and efficacy of coenzyme Q10 as adjunctiie therapy in heart failure. Molec. Aspects Med. 15 (Supplement): S287-S294. Published Material

Battino, M.; Fen-i, E.; Gorini, A.; Villa, R.F.; Huertas, J.F.R.; Fioreilla, P.; Genova, M.L.; Lenaz, G.; Marchetti, M. 1992. Natural distribution and occurrence of coenzyme Q homologues. Membrane Biochemistry 9: 179-190. Published Material

Bertelli, A.; and Runca, G. 1990. Carnitine and coenzyme Q10: biochemical properties and functions, synergism and complenentary action. Int J Tissue React 12 (3): 183-186. Published Material

Budavari, S.; O’Neil, M.J.; Smith, A.; Heckelman, P.E.; Kinneary, J.F. (Eds.). 1996. The Merck Index. An Encyclopedia of Chemicals, Drugs and Biologicals. Twelfth Edition. Merck & Co., Inc., New Jersey, p. 1679. Published Material

Chiba, T.; Watanabe, T.; Kume, Y.; Sugiyama, K.; Shiojirl, H. 1972a. Toxicological studies of ubiquinone-10 (I) Acute toxicity test in rats and mice and subacute and chronic toxicity tests in rats. Oyo Yakuri 6: 769-779. Abstract in English, Also cited in Folkers and Morishita, 1987. Published Material

Chiba, T.; Sugiyama, K.; Kume, Y.; Shiojiri, H.; Watanabe, T.; Ozeki, M, 1972b. Toxicological studies of ubiquinone-IO (II) Subacute toxicity test in rabbits. Oyo Yakuri 6:781-786. Abstract in English. Also cited in Folkers and Morishita, 1987. Published Material

Crane, F.L.; Sun, 1.L.; Sun, E.E. 1993. The essential functions of coenzyme Q. Clin Investig 71: S55-S59. Cited In: Kontush et al., 1999. Published Material

Czerniak, R. 2001. Gender-based differences in pharmacokinetics in laboratary animal models. Int J Toxicol 20 (3): 161-163. Published Material

Edlund, P.O. 1988. Determination of coenzyme Q10, a-tocopherol and cholesterol in biological samples by coupled-column liquid chromatography with coulometric and ultraviolet detection. J Chromatogr 425: 87. Cited In: Kontush et al., 1997. Published Material

Emster, L.; and Datlner, G. 1995. Biochemical, physiological and medical aspects of ubiquinone function. Biochimica et Biophysics Acta 1271: 195-204. Published Material

Ernster, L.; and Forsmark-Andree, P. 1993. Ubiquinol: An endogenous antioxidant in aerobic organisms. Clin Invest 71: S60. Cited In: Kontush et al., 1997. Published Material

Folkers, K.; and Moriihita, M. 1987. Critique of the metabolism, pharmacokinetics, and toxicology of Coenzyme Q10. Chemiker-Zeitung 111 (4): 139-143. Published Material

Forsmark-Andree, P.; Lee, C.-P.; Daltner, G.; Ernster, L. 1997. Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles. Free Radic Biol Med 22: 391-400. Cited In: Ibrahim et al., 2000. Published Material

Frei B.; Kim, M.C.; Ames, B.N. 1990. Ubiquinol-10 is an effective fipid-soluble antioxidant at physiological concentrations. Proc Watt Acad Sci 87: 4879-4883. Published Material

Hofman-Bang, C.; Rehnquist, N.; Swedberg, K., et al. 1995. Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart faiiure. J Cardiac Failure 1: 101-107. Cited In: Tran et al., 2001. Published Material

Hughes, K.; Lee, B-L.;, Feng, X.; Lee, J.; Ong, C.N. 2002. Coenzyme Q10 and differences in coronary heart disease risk in Asian Indians and Chinese. FFCS Radic Biol Ned 32 (2):132-138. Published Material

Huntington Study Group, The. 2001. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington’s disease. Neurology 57: 397-404. Published Material

Ibrahim, W.H.; Bhagavan, H.N.; Chopra, R.K.; Chow, C.K. 2000, Dietary coenzyme Q10 and vitamin E alter the status of these compounds in rat tissues and mitochondria. J Nutr 130 (9): 2343-2348. Published Material

Kaikkonen, J.; Nyyssonen, K.; Salonen, J.T. 1999. Measurement and stability of plasma reduced, oxidized and total coenzyme Q10 in humans. Stand J Clin Lab Invest 59: 457-466. Published Material

Kelso, G.F.; Porteous, C.M.; Hughes, G.; Ledgerwood, E.C.; Gane, A.M.; Smith, R.A.; Murphy, M.P. 2002. Prevention of mitochondrial oxidative damage using targeted antioxidants. Ann NY Acad Sci 959 (April): 263-274. Published Material

Kontush, A.; Schippling, S.; Spranger, 7.; Beisiegel, U. 1999. Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile? BioFactors 9:225-229. Published Material

Kontush, A.; Reich, A.; Baum, K.; Spranger, T.; Finckh, 8.; KohlschGtter, A.; Beisiegel, U. 1997. Plasma ubiquind-10 is decreased in patients with hyperiipidaemia. Atherosclerosis 129: 119-126. Published Material

Lagendijk, J.; Ubbink, J.B.; Delport, R.; Vermaak, W.J.H.; Human, J.A. 1997. Ubiquinol/ubiquinone ratio as a marker of oxidative stress in coronary artery disease. Research Communications in Molecular Pathology and Pharmacology 95 (1): 11-20. Published Material

Lansjoen, P.H.; Langsjoen, P.H.; Fotkers, K. 1990. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 65: 521-523. Published Material

Lass, A.; and Sohal, R.S. 1999. Comparisons of coenzyme Q bound to mitochondrial membrane proteins among different mammalian species. Free Radic Biol Med 27 (1-2) 220-226. Published Material

Lenaz, G. 2001. A critical appraisal of the mitochondrial coenzyme Q pool. FEBS Lett 509 (2): 151-155. Published Material

Matthews, R.T.; Yang, L.; Browns, S.; Baik, M.; Beal, M.F. 1998. Goenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA 95 (15) :8892-8897. Published Material

Micromedex. Healthcare series. Ubidecarenone. Micromedex, inc., Englewood, CO. Cited in: Tran et al., 2001. Published Material

Miles, M.V.; Horn, P.S.; Morrison, J.A:; Tang, P.H.; DeGrauw, T.; Pesce, A.J. 2003. Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in selfreported healthy adults, Clinica Chimica Acta 332: 123-132. Published Material

Mohr, D.; Bowry, V.W.; Stocker, R. 1992. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta 1126: 247-254. Published Material

Mugford, CA.; and Kedderis, G.L. 1998. Sex-dependent metabolism of xenobiotics. Drug Metab Rev 30 (3): 441-498. Published Material

Noack, H.; Kube, U.; Augustin, W. 1994. Relations between tocopherol depletion and coenzyme Q during lipid peroxidation in rat liver mitochondria. Free Radic. Res. 20: 375-386. Cited In: Ibrahim et al., 2000. Published Material

Nohl, H.; Kozlov, A.V.; Staniek, K.; Gifle, L. 2001. The multiple functions of coenzyme Q. Bioorg Chem 29 (1): 1-13. Published Material

Nohl, H.; Gille, L.; Staniek, K. 1998. The biochemical, pathophysiological, and medical aspects of ubiquinone function. Ann NY Acad Sci 854: 394-409. Published Material

Notake, Y., Tamura, S.; Toyoshima, S., Fujita, H., Suzuki, Y. and Chiba, T. 3972. Effects of coenzyme Q10 on development of the fetuses and neonates in rats and mice. Iyakuhin Kenkyu 3 (3): 306-315. Abstract in English. Also cited in Folkers and Morishita, 1987. Published Material

Okamoto, T.; Matsuya; T.; Fukunaga, Y.; Kishi, T.; Yamagami, T. 1989. Human serum ubiquinol-10 levels and relationship to serum lipids. Int J Vit Nutr Res 59: 288. Published Material

Pampori, N.A.; and Shapiro, B.H. 1999. Gender differences in the responsiveness of the sex-dependent isoforms of hepatic P450 to the feminine plasma growth hormone profile. Endocrinology 140 (3): 1245-1254. Published Material

Pepping, J. 1999. Coenzyme Q10. Am J Health Syst Pharm 56 (6): 519-521. Published Material

Podda, M.; Weber, C.; Traber, M.G.; .Packer, L. 1996. Simultaneous determination of tissue tocopherols, tocotrienols, ubiquinols, and ubiquinones, Journal of Lipid Research 37: 893-901. Published Material

Runquist, M.; Parmtyd, I.; Thelin, A.; Chojnacki, T.; Daliner, G. 1995. Distribution of branch point prenyltransferases in regions of bovine brain. J Neurochem 65: 2299-2306. Cited In: Turunen et al., 2004. Published Material

Schoepp, G. 1997. Is coenzyme Q10 (ubiquinone) effective for the treatment of heart failure? Pharmacy Practice (Canada) 13 (March): 31-32. Published Material

Schultz, J.R.; Ellerby, L.M.; Gralla, E.B.; Valentine, J.S.; Clarke, C.F. 1996. Autoxidation of ubiquinol-6 is independent of superoxide dismutase. Biochemistry 35: 6595. Cited In: Villalba et al., 2000. Published Material

Shapiro, B.H.; Agrawal; A.K,; Pampori, N.A. 1995. Gender differences in drug metabolism regulated by growth hormone. Int J Biochem Cell Biol 27 (1): 9-20. Published Material

Shults, C.W.; Oakes, D.; Kieburtz, K.; Beat, M.F.; Hass, R.; Plumb, S.; Juncos, J-L.; Nutt, J.; Shouison, I.; Carter, J.; Kompoliti, K.; Perlmutter, J.S.; Reich, S.; Stern, M.; Watts, R.L.; Kurlan, R.; Molho, E.; Harrison, M.; Lew, N. 2002. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. The Parkinson Study Group. Arch Neural 59 (10): 1541-1550. Abstract only. Published Material Published Material

Singh, RB.; Niaz, M.A.; Rastogi, V.; Rastogi, S.S. 1998. Coenzyme Q10 in cardiovascutar disease. JAPI 46 (3): 299-306. Published Material

Stocker, R.; and Frei, B. 1991. Endogenous antioxidant defenses in human blood plasma. In: sies, H. (Ed.). Oxidative Stress: Oxidants and Antioxidants. Academic Press, San Diego, pp. 213. Cited In: Villalba et al., 2000. Published Material

Stocker, R.; and Suarna, C. 1993. Extracellular reduction of ubiquinone-1 and -10 by human Hep G2 and blood ceils. Biochim Biophys Acta 1158: 15-22, Cited In: Kontush et al., 1999 and Villalba et al., 2000. Published Material

Takahashi, T.; Okamoto, T,; Mori, K.; Sayo, H.; Kishi, T. 1993. Distribution of ubiquinone and ubiquinol homologues in rat tissues and subcellular fractions. Lipids 28: 803-809. Published Material

Tang, P.H.; Miles, M.V.; Miles, L.; Quinlan, J.; Wong, B.; Wenisch, A,; Bove, K. 2004. Measurement of reduced and oxidized coenzyme Q9 and coenzyme Q10 levels in mouse tissues by HPLC with coulometric detection. Clinica Chimica Acta 341: 173-184. Published Material

Thomas, S.R.; Witting, P-K.; Stocker, R. 1999. A role for reduced coenzyme Q in atherosclerosis? BioFactors 9: 207-224. Published Material

Thomas, S.R.; Neuzil, J. ; Stocker, R. 1996. Co-supplementation with coenzyme Q prevents the pro-oxidant effect of a-tocopherol and increases the resistance of low-density lipoprotein towards transition metal-dependent oxidation initiation. Arterioscler Thromb Vast Biol 16: 687-696. Cited In: Thomas et al., 1999. Published Material

Tran, M.T.; Mitchell, T.M.; Kennedy, D.T.; Giles, J.T. 2001. Role of coenzyme Q10 in chronic heart failure, angina, and hypertension. Pharmacotherapy 21 (7): 797-806. Published Material

Turunen, M.; Olsson, J:; Dallner, G. 2004. Metabolism and function of coenzyme Q. Biochimica et Biophysics Acta 1660: 171-199. Published Material

Villalba, J.M.; Lopez-Lluch, G.; Santos-Ocana, C.; Rodriguez-Aguilera, J.C.; Navas, P. 2000. Extramitochondrial functions of coenzyme Q, In: Kagan, V-E. and.Quinn, P.J. (Eds.). Coenzyme Q: Molecular Mechanisms in Health and Disease. CRC Press, New York, pp. 83-98. Published Material

Weber, C.; Jakobsen, T.S.; Mortensen, S.A.; Paulsen, G.; Holmer, G. 1994. Effect of dietary coenzyme Q10 as an antioxidant in human plasma. Molec Aspects Med 15: s97-s102. Published Material

Williams, K.D., Maneke, J.D., AbdelHameed, M., Hall, R.L., Patmer, T.E., Kitano, M. and Hidaka, T. 1999. 52-Week oral gavage chronic toxicity study with ubiquinone in rats with a 4-week recovery. J Agric Food Chem 47: 3756-3763. Published Material

Wittenstein, B.; Klein, E.M.; Finckh, B.; Ullrich, K.; Kohlschutter, A. 2002. Plasma antioxidants in pediatric patients with glycogen storage disease, diabetes mellitus, and hypercholesterolemia. Free Radical Biology & Medicine 33 (1): 103-110. Published Material

Yamamoto, Y.; and Yamashita, S. 1999. Piasma ubiquinone,to ubiquinol ratio in patients with hepatitis, cirrhosis, and hepatoma, and in patients treated with percutaneous transluminal coronary reperfusion. Molec Aspects Med 18 (Supplement): s79-s84. Published Material

Yamamoto, Y.; and Yamashita, S. 1997. Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress. Molec Aspects Med 18 (Supplement): s79-s84. Published Material

Yamashita, S.; and Yamamoto, Y. 1997. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Anal Biochem 250: 66-73. Published Material

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